DegronMD

Uniprot ID: Q9C0K0

Source protein: B-cell lymphoma/leukemia 11B

Source gene: BCL11B

Class: DEG_SCF_FBW7_1

Location: 259:264

E3 ligase: FBXW7

DEGRON score: 0.9403

ASA_SCORE: 88.5

COIL: 0.6873

CONS_SCORE: 0.5189

DSS_SCORE: 0.5487

HELIX: 0.0157

FCONS_SCORE: 1.0869

RIG_SCORE: 0.6826

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P271Q	TCGA-86-8358	LUAD	TCGA	LTPRLT	DEG_SCF_FBW7_1	0.1389
p.T260M	TCGA-AJ-A3BG	UCEC	TCGA	LTPRLT	DEG_SCF_FBW7_1	0.8534
p.T260M	TCGA-CM-6162	COAD	TCGA	LTPRLT	DEG_SCF_FBW7_1	0.8534
p.E262K	DO233261	GACA	ICGC	LTPRLT	DEG_SCF_FBW7_1	0.7022
p.G265W	DO36360	PRAD	ICGC	LTPRLT	DEG_SCF_FBW7_1	0.3056
p.E263K	DO50301	SKCM	ICGC	LTPRLT	DEG_SCF_FBW7_1	0.7022
p.P266A	SIDM00032	Bladder Carcinoma	GDSC	LTPRLT	DEG_SCF_FBW7_1	0.2778
p.P266A	ACH-000839	Bladder Cancer	CCLE	LTPRLT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0K0	B-cell lymphoma/leukemia 11B	DEG_SCF_FBW7_1	259:264	LTPRLT	FBXW7	0.9403	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons