DegronMD

Uniprot ID: Q9C0K0

Source protein: B-cell lymphoma/leukemia 11B

Source gene: BCL11B

Class: DEG_APCC_DBOX_1

Location: 102:110

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9126

ASA_SCORE: 103.1

COIL: 0.6822

CONS_SCORE: 0.3932

DSS_SCORE: 0.6575

HELIX: 0.039

FCONS_SCORE: 1.0095

RIG_SCORE: 0.6521

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E111K	TCGA-2W-A8YY	CESC	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	0.3056
p.E111K	DO223732	CESC	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	0.3056
p.E111K	DO220841	MELA	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	0.3056
p.E111K	SIDM01083	Oral Cavity Carcinoma	GDSC	SRSELRKVS	DEG_APCC_DBOX_1	0.3056
p.E111K	ACH-000254	Head and Neck Cancer	CCLE	SRSELRKVS	DEG_APCC_DBOX_1	0.3056
p.E111K	SCC-15	upper_aerodigestive_tract	COSMIC	SRSELRKVS	DEG_APCC_DBOX_1	0.3056
p.P112L	TCGA-50-5055	LUAD	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	0.2778
p.P112L	DO25454	LUAD	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	0.2778
p.P112L	DO229446	SKCA	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	0.2778
p.E114D	TCGA-AP-A1DV	UCEC	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	0.2222
p.E114D	DO43186	UCEC	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	0.2222
p.E105K	TCGA-B5-A11E	UCEC	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	0.591
p.E105K	TCGA-CG-5723	STAD	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	0.591
p.E105K	DO38376	STAD	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	0.591
p.E105K	DO41644	UCEC	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	0.591
p.G116E	TCGA-BF-A1Q0	SKCM	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	0.1667
p.G116E	DO47374	SKCM	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	0.1667
p.D94E	TCGA-BF-A1Q0	SKCM	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	0.1111
p.D94E	DO47374	SKCM	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	0.1111
p.V113M	TCGA-EB-A3Y6	SKCM	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	0.25
p.V113M	DO38081	SKCM	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	0.25
p.R103H	TCGA-EO-A22R	UCEC	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	0.8244
p.R103H	DO42713	UCEC	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	0.8244
p.S104C	TCGA-EO-A3L0	UCEC	TCGA	SRSELRKVS	DEG_APCC_DBOX_1	0.643
p.S104C	DO219775	UCEC	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	0.643
p.G116R	DO1131	BRCA	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	0.1667
p.G116R	DO218900	SKCA	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	0.1667
p.R115H	DO227549	COCA	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	0.1944
p.R99H	DO233634	GACA	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	0.25
p.P117T	DO229024	LICA	ICGC	SRSELRKVS	DEG_APCC_DBOX_1	0.1389
p.P98L	SIDM00798	Rhabdomyosarcoma	GDSC	SRSELRKVS	DEG_APCC_DBOX_1	0.2222
p.L93M	SIDM01206	Neuroblastoma	GDSC	SRSELRKVS	DEG_APCC_DBOX_1	0.0833
p.L93M	ACH-000310	Neuroblastoma	CCLE	SRSELRKVS	DEG_APCC_DBOX_1	0.0833
p.L93M	ACH-002248	Neuroblastoma	CCLE	SRSELRKVS	DEG_APCC_DBOX_1	0.0833
p.L93M	IMR-5	autonomic_ganglia	COSMIC	SRSELRKVS	DEG_APCC_DBOX_1	0.0833
p.S97I	ACH-000072	Leukemia	CCLE	SRSELRKVS	DEG_APCC_DBOX_1	0.6389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRSELRKVS

Degron related mutations and impact score

Drug responses associated with BCL11B mutations

All proteins holding degron of SRSELRKVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0K0	B-cell lymphoma/leukemia 11B	DEG_APCC_DBOX_1	102:110	SRSELRKVS	APC,CDC20,FZR1	0.9126	More...