DegronMD

Uniprot ID: Q6X4W1

Source protein: NMDA receptor synaptonuclear signaling and neuronal migration factor

Source gene: NSMF

Class: DEG_APCC_DBOX_1

Location: 262:270

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5236

ASA_SCORE: 105.0889

COIL: 0.5107

CONS_SCORE: 0.4992

DSS_SCORE: 0.4451

HELIX: 0.4409

FCONS_SCORE: 1.0293

RIG_SCORE: 0.7687

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A276T	TCGA-D1-A103	UCEC	TCGA	FRKHLRMVG	DEG_APCC_DBOX_1	0.1667
p.Q277H	TCGA-EK-A2R8	CESC	TCGA	FRKHLRMVG	DEG_APCC_DBOX_1	0.1389
p.M258V	DO219018	BLCA	ICGC	FRKHLRMVG	DEG_APCC_DBOX_1	0.2222
p.I255N	DO222769	COCA	ICGC	FRKHLRMVG	DEG_APCC_DBOX_1	0.1389
p.C260Y	DO50835	LICA	ICGC	FRKHLRMVG	DEG_APCC_DBOX_1	0.2778
p.H256N	DO51776	STAD	ICGC	FRKHLRMVG	DEG_APCC_DBOX_1	0.1667
p.R266Q	DO38336	STAD	ICGC	FRKHLRMVG	DEG_APCC_DBOX_1	0.7329
p.V254I	DO41784	UCEC	ICGC	FRKHLRMVG	DEG_APCC_DBOX_1	0.1111
p.A255V	SIDM00118	Colorectal Carcinoma	GDSC	FRKHLRMVG	DEG_APCC_DBOX_1	0.1389
p.A255V	HCC2998	large_intestine	COSMIC	FRKHLRMVG	DEG_APCC_DBOX_1	0.1389
p.A253V	ACH-001081	Colon/Colorectal Cancer	CCLE	FRKHLRMVG	DEG_APCC_DBOX_1	0.0833
p.A253V	HCC2998	large_intestine	COSMIC	FRKHLRMVG	DEG_APCC_DBOX_1	0.0833
p.T270P	HCC-366	lung	COSMIC	FRKHLRMVG	DEG_APCC_DBOX_1	0.7031
p.R266W	SU-DHL-10	haematopoietic_and_lymphoid_tissue	COSMIC	FRKHLRMVG	DEG_APCC_DBOX_1	0.8634
p.T272P	HCC-366	lung	COSMIC	FRKHLRMVG	DEG_APCC_DBOX_1	0.2778
p.R264W	SU-DHL-10	haematopoietic_and_lymphoid_tissue	COSMIC	FRKHLRMVG	DEG_APCC_DBOX_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6X4W1	NMDA receptor synaptonuclear signaling and neuronal migration factor	DEG_APCC_DBOX_1	262:270	FRKHLRMVG	APC,CDC20,FZR1	0.5236	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons