DegronMD

Uniprot ID: Q5TBK1

Source protein: NEDD4-binding protein 2-like 1

Source gene: N4BP2L1

Class: DEG_APCC_DBOX_1

Location: 40:48

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7878

ASA_SCORE: 50.4222

COIL: 0.3874

CONS_SCORE: 0.6247

DSS_SCORE: 0.6459

HELIX: 0.0134

FCONS_SCORE: 0.9813

RIG_SCORE: 0.7419

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R41G	TCGA-DF-A2KN	UCEC	TCGA	FRKHLYLLR	DEG_APCC_DBOX_1	0.7568
p.R41G	DO223282	UCEC	ICGC	FRKHLYLLR	DEG_APCC_DBOX_1	0.7568
p.G49D	DO218693	GACA	ICGC	FRKHLYLLR	DEG_APCC_DBOX_1	0.3056
p.R36S	DO228976	LICA	ICGC	FRKHLYLLR	DEG_APCC_DBOX_1	0.2222
p.Q48K	DO229041	LICA	ICGC	FRKHLYLLR	DEG_APCC_DBOX_1	0.6944
p.N46K	DO229045	LICA	ICGC	FRKHLYLLR	DEG_APCC_DBOX_1	0.6918
p.R53K	DO36881	READ	ICGC	FRKHLYLLR	DEG_APCC_DBOX_1	0.1944
p.R52I	DO47491	SKCM	ICGC	FRKHLYLLR	DEG_APCC_DBOX_1	0.2222
p.K44R	DO42793	UCEC	ICGC	FRKHLYLLR	DEG_APCC_DBOX_1	0.7237
p.R36C	ACH-000854	Myeloma	CCLE	FRKHLYLLR	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TBK1	NEDD4-binding protein 2-like 1	DEG_APCC_DBOX_1	40:48	FRKHLYLLR	APC,CDC20,FZR1	0.7878	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons