DegronMD - Q5TBK1(N4BP2L1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R41G	TCGA-DF-A2KN	UCEC	TCGA	FRKHLYLLR	DEG_APCC_DBOX_1	40:48	Mutation altering degron motif	0.7568
p.R41G	DO223282	UCEC	ICGC	FRKHLYLLR	DEG_APCC_DBOX_1	40:48	Mutation altering degron motif	0.7568
p.G49D	DO218693	GACA	ICGC	FRKHLYLLR	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.3056
p.R36S	DO228976	LICA	ICGC	FRKHLYLLR	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.2222
p.Q48K	DO229041	LICA	ICGC	FRKHLYLLR	DEG_APCC_DBOX_1	40:48	Mutation altering degron motif	0.6944
p.N46K	DO229045	LICA	ICGC	FRKHLYLLR	DEG_APCC_DBOX_1	40:48	Mutation altering degron motif	0.6918
p.R53K	DO36881	READ	ICGC	FRKHLYLLR	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.1944
p.R52I	DO47491	SKCM	ICGC	FRKHLYLLR	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.2222
p.K44R	DO42793	UCEC	ICGC	FRKHLYLLR	DEG_APCC_DBOX_1	40:48	Mutation altering degron motif	0.7237
p.R210K	SIDM01015	Chronic Myelogenous Leukemia	GDSC	NSYTEFP	CBL_PTK	213:219	Mutation rewiring degron network	0.25
p.R210K	ACH-000326	Leukemia	CCLE	NSYTEFP	CBL_PTK	213:219	Mutation rewiring degron network	0.25
p.R210K	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	NSYTEFP	CBL_PTK	213:219	Mutation rewiring degron network	0.25
p.E217K	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	NSYTEFP	CBL_PTK	213:219	Mutation altering degron motif	0.591
p.E217K	ACH-000226	Lymphoma	CCLE	NSYTEFP	CBL_PTK	213:219	Mutation altering degron motif	0.591
p.E217K	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	NSYTEFP	CBL_PTK	213:219	Mutation altering degron motif	0.591
p.G225S	SIDM00454	Rhabdomyosarcoma	GDSC	NSYTEFP	CBL_PTK	213:219	Mutation rewiring degron network	0.1667
p.G225S	ACH-000689	Sarcoma	CCLE	NSYTEFP	CBL_PTK	213:219	Mutation rewiring degron network	0.1667
p.G225S	RH-18	soft tissue	COSMIC	NSYTEFP	CBL_PTK	213:219	Mutation rewiring degron network	0.1667
p.H224Y	SIDM01237	Hepatocellular Carcinoma	GDSC	NSYTEFP	CBL_PTK	213:219	Mutation rewiring degron network	0.1944
p.H224Y	ACH-001021	Liver Cancer	CCLE	NSYTEFP	CBL_PTK	213:219	Mutation rewiring degron network	0.1944
p.H224Y	C3A	liver	COSMIC	NSYTEFP	CBL_PTK	213:219	Mutation rewiring degron network	0.1944
p.A223V	SIDM00151	Ovarian Carcinoma	GDSC	NSYTEFP	CBL_PTK	213:219	Mutation rewiring degron network	0.2222
p.A223V	ACH-000966	Ovarian Cancer	CCLE	NSYTEFP	CBL_PTK	213:219	Mutation rewiring degron network	0.2222
p.A223V	IGROV-1	ovary	COSMIC	NSYTEFP	CBL_PTK	213:219	Mutation rewiring degron network	0.2222
p.R36C	ACH-000854	Myeloma	CCLE	FRKHLYLLR	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

N4BP2L1

UniProt ID: Q5TBK1

Entrez ID: 90634

Protein name: NEDD4-binding protein 2-like 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for N4BP2L1 in