DegronMD

Uniprot ID: Q5TBK1

Source protein: NEDD4-binding protein 2-like 1

Source gene: N4BP2L1

Class: CBL_PTK

Location: 213:219

E3 ligase: CBL

DEGRON score: 0.9927

ASA_SCORE: 86.7714

COIL: 0.7783

CONS_SCORE: 0.4415

DSS_SCORE: 0.3992

HELIX: 0.1856

FCONS_SCORE: 1.0066

RIG_SCORE: 0.7691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R210K	SIDM01015	Chronic Myelogenous Leukemia	GDSC	NSYTEFP	CBL_PTK	0.25
p.R210K	ACH-000326	Leukemia	CCLE	NSYTEFP	CBL_PTK	0.25
p.R210K	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	NSYTEFP	CBL_PTK	0.25
p.E217K	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	NSYTEFP	CBL_PTK	0.591
p.E217K	ACH-000226	Lymphoma	CCLE	NSYTEFP	CBL_PTK	0.591
p.E217K	SUP-M2	haematopoietic_and_lymphoid_tissue	COSMIC	NSYTEFP	CBL_PTK	0.591
p.G225S	SIDM00454	Rhabdomyosarcoma	GDSC	NSYTEFP	CBL_PTK	0.1667
p.G225S	ACH-000689	Sarcoma	CCLE	NSYTEFP	CBL_PTK	0.1667
p.G225S	RH-18	soft_tissue	COSMIC	NSYTEFP	CBL_PTK	0.1667
p.H224Y	SIDM01237	Hepatocellular Carcinoma	GDSC	NSYTEFP	CBL_PTK	0.1944
p.H224Y	ACH-001021	Liver Cancer	CCLE	NSYTEFP	CBL_PTK	0.1944
p.H224Y	C3A	liver	COSMIC	NSYTEFP	CBL_PTK	0.1944
p.A223V	SIDM00151	Ovarian Carcinoma	GDSC	NSYTEFP	CBL_PTK	0.2222
p.A223V	ACH-000966	Ovarian Cancer	CCLE	NSYTEFP	CBL_PTK	0.2222
p.A223V	IGROV-1	ovary	COSMIC	NSYTEFP	CBL_PTK	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TBK1	NEDD4-binding protein 2-like 1	CBL_PTK	213:219	NSYTEFP	CBL	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons