DegronMD

Uniprot ID: Q92698

Source protein: DNA repair and recombination protein RAD54-like

Source gene: RAD54L

Class: DEG_APCC_DBOX_1

Location: 51:59

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9993

ASA_SCORE: 84.0778

COIL: 0.7536

CONS_SCORE: 0.3299

DSS_SCORE: 0.4446

HELIX: 0.1667

FCONS_SCORE: 1.0921

RIG_SCORE: 0.7213

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q42R	TCGA-12-0657	GBM	TCGA	FRKPLSQLT	DEG_APCC_DBOX_1	0.0833
p.Q42R	DO13911	GBM	ICGC	FRKPLSQLT	DEG_APCC_DBOX_1	0.0833
p.Q69H	TCGA-B5-A11U	UCEC	TCGA	FRKPLSQLT	DEG_APCC_DBOX_1	0.0556
p.Q69H	DO227646	COCA	ICGC	FRKPLSQLT	DEG_APCC_DBOX_1	0.0556
p.Q69H	DO40804	UCEC	ICGC	FRKPLSQLT	DEG_APCC_DBOX_1	0.0556
p.L55F	TCGA-DK-A3WW	BLCA	TCGA	FRKPLSQLT	DEG_APCC_DBOX_1	0.6981
p.L55F	TCGA-LP-A4AV	CESC	TCGA	FRKPLSQLT	DEG_APCC_DBOX_1	0.6981
p.L55F	DO481	BLCA	ICGC	FRKPLSQLT	DEG_APCC_DBOX_1	0.6981
p.L55F	DO44275	CESC	ICGC	FRKPLSQLT	DEG_APCC_DBOX_1	0.6981
p.C46F	DO228978	LICA	ICGC	FRKPLSQLT	DEG_APCC_DBOX_1	0.1944
p.P50S	DO222810	MELA	ICGC	FRKPLSQLT	DEG_APCC_DBOX_1	0.3056
p.P63S	DO224656	PACA	ICGC	FRKPLSQLT	DEG_APCC_DBOX_1	0.2222
p.R52W	SIDM00095	Glioblastoma	GDSC	FRKPLSQLT	DEG_APCC_DBOX_1	0.8634
p.R52W	ACH-000504	Brain Cancer	CCLE	FRKPLSQLT	DEG_APCC_DBOX_1	0.8634
p.R52W	SNB75	central_nervous_system	COSMIC	FRKPLSQLT	DEG_APCC_DBOX_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92698	DNA repair and recombination protein RAD54-like	DEG_APCC_DBOX_1	51:59	FRKPLSQLT	APC,CDC20,FZR1	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons