DegronMD

Uniprot ID: Q9NQR4

Source protein: Omega-amidase NIT2

Source gene: NIT2

Class: DEG_APCC_DBOX_1

Location: 4:12

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5946

ASA_SCORE: 21.7889

COIL: 0.1832

CONS_SCORE: 0.5544

DSS_SCORE: 0.1683

HELIX: 0.0067

FCONS_SCORE: 1.5389

RIG_SCORE: 0.9088

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R5C	TCGA-27-2523	GBM	TCGA	FRLALIQLQ	DEG_APCC_DBOX_1	0.8301
p.R5C	TCGA-DU-7012	LGG	TCGA	FRLALIQLQ	DEG_APCC_DBOX_1	0.8301
p.R5C	DO10908	GBM	ICGC	FRLALIQLQ	DEG_APCC_DBOX_1	0.8301
p.R5C	DO22187	LGG	ICGC	FRLALIQLQ	DEG_APCC_DBOX_1	0.8301
p.R5C	DO51061	PRAD	ICGC	FRLALIQLQ	DEG_APCC_DBOX_1	0.8301
p.D19Y	TCGA-AX-A2HC	UCEC	TCGA	FRLALIQLQ	DEG_APCC_DBOX_1	0.1389
p.D19Y	DO41572	UCEC	ICGC	FRLALIQLQ	DEG_APCC_DBOX_1	0.1389
p.N20D	TCGA-BH-A18G	BRCA	TCGA	FRLALIQLQ	DEG_APCC_DBOX_1	0.1111
p.N20D	DO3686	BRCA	ICGC	FRLALIQLQ	DEG_APCC_DBOX_1	0.1111
p.S15F	TCGA-CV-A468	HNSC	TCGA	FRLALIQLQ	DEG_APCC_DBOX_1	0.25
p.S15F	DO52070	HNSC	ICGC	FRLALIQLQ	DEG_APCC_DBOX_1	0.25
p.A7V	TCGA-DF-A2KU	UCEC	TCGA	FRLALIQLQ	DEG_APCC_DBOX_1	0.5825
p.A7V	DO223286	UCEC	ICGC	FRLALIQLQ	DEG_APCC_DBOX_1	0.5825
p.R5H	TCGA-EO-A3KX	UCEC	TCGA	FRLALIQLQ	DEG_APCC_DBOX_1	0.8244
p.R5H	DO219774	UCEC	ICGC	FRLALIQLQ	DEG_APCC_DBOX_1	0.8244
p.N20K	DO225004	BRCA	ICGC	FRLALIQLQ	DEG_APCC_DBOX_1	0.1111
p.R5P	SIDM00603	Head and Neck Carcinoma	GDSC	FRLALIQLQ	DEG_APCC_DBOX_1	0.7512
p.R5P	ACH-001543	Head and Neck Cancer	CCLE	FRLALIQLQ	DEG_APCC_DBOX_1	0.7512
p.R5P	KOSC-2	upper_aerodigestive_tract	COSMIC	FRLALIQLQ	DEG_APCC_DBOX_1	0.7512

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQR4	Omega-amidase NIT2	DEG_APCC_DBOX_1	4:12	FRLALIQLQ	APC,CDC20,FZR1	0.5946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons