DegronMD - Q9NQR4(NIT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R5C	TCGA-27-2523	GBM	TCGA	FRLALIQLQ	DEG_APCC_DBOX_1	4:12	Mutation altering degron motif	0.8301
p.R5C	TCGA-DU-7012	LGG	TCGA	FRLALIQLQ	DEG_APCC_DBOX_1	4:12	Mutation altering degron motif	0.8301
p.R5C	DO10908	GBM	ICGC	FRLALIQLQ	DEG_APCC_DBOX_1	4:12	Mutation altering degron motif	0.8301
p.R5C	DO22187	LGG	ICGC	FRLALIQLQ	DEG_APCC_DBOX_1	4:12	Mutation altering degron motif	0.8301
p.R5C	DO51061	PRAD	ICGC	FRLALIQLQ	DEG_APCC_DBOX_1	4:12	Mutation altering degron motif	0.8301
p.R255H	TCGA-AA-3679	COAD	TCGA	KRSDLYAVE	DEG_APCC_DBOX_1	264:272	Mutation rewiring degron network	0.0833
p.R255H	DO8890	COAD	ICGC	KRSDLYAVE	DEG_APCC_DBOX_1	264:272	Mutation rewiring degron network	0.0833
p.D19Y	TCGA-AX-A2HC	UCEC	TCGA	FRLALIQLQ	DEG_APCC_DBOX_1	4:12	Mutation rewiring degron network	0.1389
p.D19Y	DO41572	UCEC	ICGC	FRLALIQLQ	DEG_APCC_DBOX_1	4:12	Mutation rewiring degron network	0.1389
p.N20D	TCGA-BH-A18G	BRCA	TCGA	FRLALIQLQ	DEG_APCC_DBOX_1	4:12	Mutation rewiring degron network	0.1111
p.N20D	DO3686	BRCA	ICGC	FRLALIQLQ	DEG_APCC_DBOX_1	4:12	Mutation rewiring degron network	0.1111
p.R255C	TCGA-BR-8078	STAD	TCGA	KRSDLYAVE	DEG_APCC_DBOX_1	264:272	Mutation rewiring degron network	0.0833
p.R255C	DO38288	STAD	ICGC	KRSDLYAVE	DEG_APCC_DBOX_1	264:272	Mutation rewiring degron network	0.0833
p.F261Y	TCGA-CV-7568	HNSC	TCGA	KRSDLYAVE	DEG_APCC_DBOX_1	264:272	Mutation rewiring degron network	0.25
p.F261Y	DO14160	HNSC	ICGC	KRSDLYAVE	DEG_APCC_DBOX_1	264:272	Mutation rewiring degron network	0.25
p.S15F	TCGA-CV-A468	HNSC	TCGA	FRLALIQLQ	DEG_APCC_DBOX_1	4:12	Mutation rewiring degron network	0.25
p.S15F	DO52070	HNSC	ICGC	FRLALIQLQ	DEG_APCC_DBOX_1	4:12	Mutation rewiring degron network	0.25
p.A7V	TCGA-DF-A2KU	UCEC	TCGA	FRLALIQLQ	DEG_APCC_DBOX_1	4:12	Mutation altering degron motif	0.5825
p.A7V	DO223286	UCEC	ICGC	FRLALIQLQ	DEG_APCC_DBOX_1	4:12	Mutation altering degron motif	0.5825
p.R5H	TCGA-EO-A3KX	UCEC	TCGA	FRLALIQLQ	DEG_APCC_DBOX_1	4:12	Mutation altering degron motif	0.8244
p.R5H	DO219774	UCEC	ICGC	FRLALIQLQ	DEG_APCC_DBOX_1	4:12	Mutation altering degron motif	0.8244
p.V260D	TCGA-FS-A1ZW	SKCM	TCGA	KRSDLYAVE	DEG_APCC_DBOX_1	264:272	Mutation rewiring degron network	0.2222
p.V260D	DO37519	SKCM	ICGC	KRSDLYAVE	DEG_APCC_DBOX_1	264:272	Mutation rewiring degron network	0.2222
p.N20K	DO225004	BRCA	ICGC	FRLALIQLQ	DEG_APCC_DBOX_1	4:12	Mutation rewiring degron network	0.1111
p.V260I	DO230311	COCA	ICGC	KRSDLYAVE	DEG_APCC_DBOX_1	264:272	Mutation rewiring degron network	0.2222
p.V260I	SIDM01174	Cervical Carcinoma	GDSC	KRSDLYAVE	DEG_APCC_DBOX_1	264:272	Mutation rewiring degron network	0.2222
p.Y269F	DO231049	LUSC	ICGC	KRSDLYAVE	DEG_APCC_DBOX_1	264:272	Mutation altering degron motif	0.7528
p.R5P	SIDM00603	Head and Neck Carcinoma	GDSC	FRLALIQLQ	DEG_APCC_DBOX_1	4:12	Mutation altering degron motif	0.7512
p.R5P	ACH-001543	Head and Neck Cancer	CCLE	FRLALIQLQ	DEG_APCC_DBOX_1	4:12	Mutation altering degron motif	0.7512
p.R5P	KOSC-2	upper aerodigestive tract	COSMIC	FRLALIQLQ	DEG_APCC_DBOX_1	4:12	Mutation altering degron motif	0.7512

Kaplan plot for NIT2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NIT2

UniProt ID: Q9NQR4

Entrez ID: 56954

Protein name: Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NIT2 in