DegronMD

Uniprot ID: Q9NQR4

Source protein: Omega-amidase NIT2

Source gene: NIT2

Class: DEG_APCC_DBOX_1

Location: 264:272

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8785

ASA_SCORE: 72.9556

COIL: 0.5242

CONS_SCORE: 0.4534

DSS_SCORE: 0.4193

HELIX: 0.419

FCONS_SCORE: 1.3028

RIG_SCORE: 0.804

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R255H	TCGA-AA-3679	COAD	TCGA	KRSDLYAVE	DEG_APCC_DBOX_1	0.0833
p.R255H	DO8890	COAD	ICGC	KRSDLYAVE	DEG_APCC_DBOX_1	0.0833
p.R255C	TCGA-BR-8078	STAD	TCGA	KRSDLYAVE	DEG_APCC_DBOX_1	0.0833
p.R255C	DO38288	STAD	ICGC	KRSDLYAVE	DEG_APCC_DBOX_1	0.0833
p.F261Y	TCGA-CV-7568	HNSC	TCGA	KRSDLYAVE	DEG_APCC_DBOX_1	0.25
p.F261Y	DO14160	HNSC	ICGC	KRSDLYAVE	DEG_APCC_DBOX_1	0.25
p.V260D	TCGA-FS-A1ZW	SKCM	TCGA	KRSDLYAVE	DEG_APCC_DBOX_1	0.2222
p.V260D	DO37519	SKCM	ICGC	KRSDLYAVE	DEG_APCC_DBOX_1	0.2222
p.V260I	DO230311	COCA	ICGC	KRSDLYAVE	DEG_APCC_DBOX_1	0.2222
p.V260I	SIDM01174	Cervical Carcinoma	GDSC	KRSDLYAVE	DEG_APCC_DBOX_1	0.2222
p.Y269F	DO231049	LUSC	ICGC	KRSDLYAVE	DEG_APCC_DBOX_1	0.7528

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQR4	Omega-amidase NIT2	DEG_APCC_DBOX_1	264:272	KRSDLYAVE	APC,CDC20,FZR1	0.8785	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons