DegronMD

Uniprot ID: Q5HYI7

Source protein: Metaxin-3

Source gene: MTX3

Class: DEG_APCC_DBOX_1

Location: 241:249

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8571

ASA_SCORE: 68.6556

COIL: 0.8969

CONS_SCORE: 0.4499

DSS_SCORE: 0.131

HELIX: 0.0431

FCONS_SCORE: 0.9447

RIG_SCORE: 0.7541

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R248W	TCGA-BR-4256	STAD	TCGA	FRLSLGGIS	DEG_APCC_DBOX_1	0.8634
p.R248W	DO38743	STAD	ICGC	FRLSLGGIS	DEG_APCC_DBOX_1	0.8634
p.S245F	DO222494	MELA	ICGC	FRLSLGGIS	DEG_APCC_DBOX_1	0.7982
p.T255M	SIDM00829	Acute Myeloid Leukemia	GDSC	FRLSLGGIS	DEG_APCC_DBOX_1	0.6111
p.T255M	ACH-000002	Leukemia	CCLE	FRLSLGGIS	DEG_APCC_DBOX_1	0.6111
p.T255M	HL-60	haematopoietic_and_lymphoid_tissue	COSMIC	FRLSLGGIS	DEG_APCC_DBOX_1	0.6111
p.G252E	SIDM00819	Kidney Carcinoma	GDSC	FRLSLGGIS	DEG_APCC_DBOX_1	0.25
p.A251T	SIDM01608	Endometrial Carcinoma	GDSC	FRLSLGGIS	DEG_APCC_DBOX_1	0.2778
p.A251T	ACH-000990	Endometrial/Uterine Cancer	CCLE	FRLSLGGIS	DEG_APCC_DBOX_1	0.2778
p.G247C	SIDM01394	Kidney Carcinoma	GDSC	FRLSLGGIS	DEG_APCC_DBOX_1	0.6489
p.L231R	CW-2	large_intestine	COSMIC	FRLSLGGIS	DEG_APCC_DBOX_1	0.0556
p.R248Q	SW1573	lung	COSMIC	FRLSLGGIS	DEG_APCC_DBOX_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5HYI7	Metaxin-3	DEG_APCC_DBOX_1	241:249	FRLSLGGIS	APC,CDC20,FZR1	0.8571	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons