DegronMD - Q5HYI7(MTX3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R248W	TCGA-BR-4256	STAD	TCGA	FRLSLGGIS	DEG_APCC_DBOX_1	241:249	Mutation altering degron motif	0.8634
p.R248W	DO38743	STAD	ICGC	FRLSLGGIS	DEG_APCC_DBOX_1	241:249	Mutation altering degron motif	0.8634
p.S245F	DO222494	MELA	ICGC	FRLSLGGIS	DEG_APCC_DBOX_1	241:249	Mutation altering degron motif	0.7982
p.R309Q	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.1389
p.R309Q	ACH-000677	Lung Cancer	CCLE	LKLTPAEE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.1389
p.R309Q	SW1573	lung	COSMIC	LKLTPAEE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.1389
p.R290W	SIDM00496	Thyroid Gland Carcinoma	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.1944
p.R290W	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.1944
p.R290W	SIDM00599	Osteosarcoma	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.1944
p.R290W	SIDM01018	Hodgkin's Lymphoma	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.1944
p.R290W	SIDM01728	Endometrial Carcinoma	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.1944
p.R290W	SIDM01682	Gastric Carcinoma	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.1944
p.R290W	SIDM01321	Pancreatic Carcinoma	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.1944
p.R290W	SIDM01574	Plasma Cell Myeloma	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.1944
p.T255M	SIDM00829	Acute Myeloid Leukemia	GDSC	FRLSLGGIS	DEG_APCC_DBOX_1	241:249	Mutation blocking phosphorylation signal	0.6111
p.T255M	ACH-000002	Leukemia	CCLE	FRLSLGGIS	DEG_APCC_DBOX_1	241:249	Mutation blocking phosphorylation signal	0.6111
p.T255M	HL-60	haematopoietic and lymphoid tissue	COSMIC	FRLSLGGIS	DEG_APCC_DBOX_1	241:249	Mutation blocking phosphorylation signal	0.6111
p.L292R	SIDM00282	Colorectal Carcinoma	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.25
p.L292R	ACH-000998	Colon/Colorectal Cancer	CCLE	LKLTPAEE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.25
p.L292R	CW-2	large intestine	COSMIC	LKLTPAEE	DEG_SCF_FBW7_2	295:302	Mutation rewiring degron network	0.25
p.G252E	SIDM00819	Kidney Carcinoma	GDSC	FRLSLGGIS	DEG_APCC_DBOX_1	241:249	Mutation rewiring degron network	0.25
p.A251T	SIDM01608	Endometrial Carcinoma	GDSC	FRLSLGGIS	DEG_APCC_DBOX_1	241:249	Mutation rewiring degron network	0.2778
p.A251T	ACH-000990	Endometrial/Uterine Cancer	CCLE	FRLSLGGIS	DEG_APCC_DBOX_1	241:249	Mutation rewiring degron network	0.2778
p.G247C	SIDM01394	Kidney Carcinoma	GDSC	FRLSLGGIS	DEG_APCC_DBOX_1	241:249	Mutation altering degron motif	0.6489
p.L231R	CW-2	large intestine	COSMIC	FRLSLGGIS	DEG_APCC_DBOX_1	241:249	Mutation rewiring degron network	0.0556
p.R248Q	SW1573	lung	COSMIC	FRLSLGGIS	DEG_APCC_DBOX_1	241:249	Mutation altering degron motif	0.7329

Kaplan plot for MTX3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTX3

UniProt ID: Q5HYI7

Entrez ID: 345778

Protein name: Metaxin-3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTX3 in