DegronMD

Uniprot ID: Q5HYI7

Source protein: Metaxin-3

Source gene: MTX3

Class: DEG_SCF_FBW7_2

Location: 295:302

E3 ligase: FBXW7

DEGRON score: 0.8345

ASA_SCORE: 97.0875

COIL: 0.7239

CONS_SCORE: 0.406

DSS_SCORE: 0.6565

HELIX: 0.2541

FCONS_SCORE: 0.9582

RIG_SCORE: 0.688

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L292R	SIDM00282	Colorectal Carcinoma	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	0.25
p.L292R	ACH-000998	Colon/Colorectal Cancer	CCLE	LKLTPAEE	DEG_SCF_FBW7_2	0.25
p.L292R	CW-2	large_intestine	COSMIC	LKLTPAEE	DEG_SCF_FBW7_2	0.25
p.R290W	SIDM00496	Thyroid Gland Carcinoma	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	0.1944
p.R290W	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	0.1944
p.R290W	SIDM00599	Osteosarcoma	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	0.1944
p.R290W	SIDM01018	Hodgkin's Lymphoma	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	0.1944
p.R290W	SIDM01728	Endometrial Carcinoma	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	0.1944
p.R290W	SIDM01682	Gastric Carcinoma	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	0.1944
p.R290W	SIDM01321	Pancreatic Carcinoma	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	0.1944
p.R290W	SIDM01574	Plasma Cell Myeloma	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	0.1944
p.R309Q	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	LKLTPAEE	DEG_SCF_FBW7_2	0.1389
p.R309Q	ACH-000677	Lung Cancer	CCLE	LKLTPAEE	DEG_SCF_FBW7_2	0.1389
p.R309Q	SW1573	lung	COSMIC	LKLTPAEE	DEG_SCF_FBW7_2	0.1389

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5HYI7	Metaxin-3	DEG_SCF_FBW7_2	295:302	LKLTPAEE	FBXW7	0.8345	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons