DegronMD

Uniprot ID: O43143

Source protein: ATP-dependent RNA helicase DHX15

Source gene: DHX15

Class: LIG_APCC_ABBA_1

Location: 482:487

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6361

ASA_SCORE: 32.2

COIL: 0.2413

CONS_SCORE: 0.7659

DSS_SCORE: 0.3953

HELIX: 0.1663

FCONS_SCORE: 1.1971

RIG_SCORE: 0.8444

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L484I	DO229028	LICA	ICGC	FRLYTE	LIG_APCC_ABBA_1	0.6063
p.E487D	TCGA-A5-A0G1	UCEC	TCGA	FRLYTE	LIG_APCC_ABBA_1	0.5647
p.E487D	TCGA-AX-A2HC	UCEC	TCGA	FRLYTE	LIG_APCC_ABBA_1	0.5647
p.E487D	DO41572	UCEC	ICGC	FRLYTE	LIG_APCC_ABBA_1	0.5647
p.E487D	DO42472	UCEC	ICGC	FRLYTE	LIG_APCC_ABBA_1	0.5647
p.C481F	TCGA-VS-A9UR	CESC	TCGA	FRLYTE	LIG_APCC_ABBA_1	0.3056
p.C481F	DO219739	CESC	ICGC	FRLYTE	LIG_APCC_ABBA_1	0.3056
p.P478S	TCGA-EE-A2MU	SKCM	TCGA	FRLYTE	LIG_APCC_ABBA_1	0.2222
p.P478S	DO37436	SKCM	ICGC	FRLYTE	LIG_APCC_ABBA_1	0.2222
p.P478T	DO229041	LICA	ICGC	FRLYTE	LIG_APCC_ABBA_1	0.2222
p.T492A	TCGA-BG-A222	UCEC	TCGA	FRLYTE	LIG_APCC_ABBA_1	0.1944
p.T492A	DO42977	UCEC	ICGC	FRLYTE	LIG_APCC_ABBA_1	0.1944
p.R475S	DO229027	LICA	ICGC	FRLYTE	LIG_APCC_ABBA_1	0.1389
p.D496H	DO223010	ESCA	ICGC	FRLYTE	LIG_APCC_ABBA_1	0.0833
p.D496H	SIDM01617	Endometrial Carcinoma	GDSC	FRLYTE	LIG_APCC_ABBA_1	0.0833
p.N497K	TCGA-VT-A80G	SARC	TCGA	FRLYTE	LIG_APCC_ABBA_1	0.0556
p.N497K	DO220287	SARC	ICGC	FRLYTE	LIG_APCC_ABBA_1	0.0556

Showing 1 to 17 of 17 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43143	ATP-dependent RNA helicase DHX15	LIG_APCC_ABBA_1	482:487	FRLYTE	APC,CDC20,FZR1	0.6361	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons