DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
FRLYTE
Uniprot ID:
O43143
Source protein:
ATP-dependent RNA helicase DHX15
Source gene:
DHX15
Class:
LIG_APCC_ABBA_1
Location:
482:487
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6361
ASA_SCORE:
32.2
COIL:
0.2413
CONS_SCORE:
0.7659
DSS_SCORE:
0.3953
HELIX:
0.1663
FCONS_SCORE:
1.1971
RIG_SCORE:
0.8444
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E487D
TCGA-A5-A0G1
UCEC
TCGA
FRLYTE
LIG_APCC_ABBA_1
0.5647
p.E487D
TCGA-AX-A2HC
UCEC
TCGA
FRLYTE
LIG_APCC_ABBA_1
0.5647
p.E487D
DO41572
UCEC
ICGC
FRLYTE
LIG_APCC_ABBA_1
0.5647
p.E487D
DO42472
UCEC
ICGC
FRLYTE
LIG_APCC_ABBA_1
0.5647
p.T492A
TCGA-BG-A222
UCEC
TCGA
FRLYTE
LIG_APCC_ABBA_1
0.1944
p.T492A
DO42977
UCEC
ICGC
FRLYTE
LIG_APCC_ABBA_1
0.1944
p.P478S
TCGA-EE-A2MU
SKCM
TCGA
FRLYTE
LIG_APCC_ABBA_1
0.2222
p.P478S
DO37436
SKCM
ICGC
FRLYTE
LIG_APCC_ABBA_1
0.2222
p.C481F
TCGA-VS-A9UR
CESC
TCGA
FRLYTE
LIG_APCC_ABBA_1
0.3056
p.C481F
DO219739
CESC
ICGC
FRLYTE
LIG_APCC_ABBA_1
0.3056
p.N497K
TCGA-VT-A80G
SARC
TCGA
FRLYTE
LIG_APCC_ABBA_1
0.0556
p.N497K
DO220287
SARC
ICGC
FRLYTE
LIG_APCC_ABBA_1
0.0556
p.D496H
DO223010
ESCA
ICGC
FRLYTE
LIG_APCC_ABBA_1
0.0833
p.D496H
SIDM01617
Endometrial Carcinoma
GDSC
FRLYTE
LIG_APCC_ABBA_1
0.0833
p.L484I
DO229028
LICA
ICGC
FRLYTE
LIG_APCC_ABBA_1
0.6063
p.R475S
DO229027
LICA
ICGC
FRLYTE
LIG_APCC_ABBA_1
0.1389
p.P478T
DO229041
LICA
ICGC
FRLYTE
LIG_APCC_ABBA_1
0.2222
Drug responses associated with DHX15 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FRLYTE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O43143
ATP-dependent RNA helicase DHX15
LIG_APCC_ABBA_1
482:487
FRLYTE
APC,CDC20,FZR1
0.6361
More...