DegronMD - O43143(DHX15)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T498I	TCGA-A5-A0G1	UCEC	TCGA	LRSNLGSVV	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1944
p.T498I	TCGA-CG-4306	STAD	TCGA	LRSNLGSVV	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1944
p.T498I	DO38567	STAD	ICGC	LRSNLGSVV	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1944
p.T498I	DO42472	UCEC	ICGC	LRSNLGSVV	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1944
p.E487D	TCGA-A5-A0G1	UCEC	TCGA	FRLYTE	LIG_APCC_ABBA_1	482:487	Mutation altering degron motif	0.5647
p.E487D	TCGA-AX-A2HC	UCEC	TCGA	FRLYTE	LIG_APCC_ABBA_1	482:487	Mutation altering degron motif	0.5647
p.E487D	DO41572	UCEC	ICGC	FRLYTE	LIG_APCC_ABBA_1	482:487	Mutation altering degron motif	0.5647
p.E487D	DO42472	UCEC	ICGC	FRLYTE	LIG_APCC_ABBA_1	482:487	Mutation altering degron motif	0.5647
p.Y499N	TCGA-AN-A0XV	BRCA	TCGA	LRSNLGSVV	DEG_APCC_DBOX_1	503:511	Mutation blocking phosphorylation signal	0.6667
p.Y499N	DO2913	BRCA	ICGC	LRSNLGSVV	DEG_APCC_DBOX_1	503:511	Mutation blocking phosphorylation signal	0.6667
p.T498A	TCGA-AX-A1CE	UCEC	TCGA	LRSNLGSVV	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1944
p.T498A	DO42280	UCEC	ICGC	LRSNLGSVV	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1944
p.T492A	TCGA-BG-A222	UCEC	TCGA	FRLYTE	LIG_APCC_ABBA_1	482:487	Mutation rewiring degron network	0.1944
p.T492A	DO42977	UCEC	ICGC	FRLYTE	LIG_APCC_ABBA_1	482:487	Mutation rewiring degron network	0.1944
p.P478S	TCGA-EE-A2MU	SKCM	TCGA	FRLYTE	LIG_APCC_ABBA_1	482:487	Mutation rewiring degron network	0.2222
p.P478S	DO37436	SKCM	ICGC	FRLYTE	LIG_APCC_ABBA_1	482:487	Mutation rewiring degron network	0.2222
p.C481F	TCGA-VS-A9UR	CESC	TCGA	FRLYTE	LIG_APCC_ABBA_1	482:487	Mutation rewiring degron network	0.3056
p.C481F	DO219739	CESC	ICGC	FRLYTE	LIG_APCC_ABBA_1	482:487	Mutation rewiring degron network	0.3056
p.N497K	TCGA-VT-A80G	SARC	TCGA	LRSNLGSVV	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1667
p.N497K	TCGA-VT-A80G	SARC	TCGA	FRLYTE	LIG_APCC_ABBA_1	482:487	Mutation rewiring degron network	0.0556
p.N497K	DO220287	SARC	ICGC	LRSNLGSVV	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1667
p.N497K	DO220287	SARC	ICGC	FRLYTE	LIG_APCC_ABBA_1	482:487	Mutation rewiring degron network	0.0556
p.D496H	DO223010	ESCA	ICGC	LRSNLGSVV	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1389
p.D496H	DO223010	ESCA	ICGC	FRLYTE	LIG_APCC_ABBA_1	482:487	Mutation rewiring degron network	0.0833
p.D496H	SIDM01617	Endometrial Carcinoma	GDSC	LRSNLGSVV	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1389
p.D496H	SIDM01617	Endometrial Carcinoma	GDSC	FRLYTE	LIG_APCC_ABBA_1	482:487	Mutation rewiring degron network	0.0833
p.L484I	DO229028	LICA	ICGC	FRLYTE	LIG_APCC_ABBA_1	482:487	Mutation altering degron motif	0.6063
p.R475S	DO229027	LICA	ICGC	FRLYTE	LIG_APCC_ABBA_1	482:487	Mutation rewiring degron network	0.1389
p.P478T	DO229041	LICA	ICGC	FRLYTE	LIG_APCC_ABBA_1	482:487	Mutation rewiring degron network	0.2222
p.Y499C	DO52345	LUSC	ICGC	LRSNLGSVV	DEG_APCC_DBOX_1	503:511	Mutation blocking phosphorylation signal	0.6667
p.S509L	DO47064	RECA	ICGC	LRSNLGSVV	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.7667
p.L514W	SIDM00483	Esophageal Carcinoma	GDSC	LRSNLGSVV	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.25
p.L514W	ACH-001654	Esophageal Cancer	CCLE	LRSNLGSVV	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.25
p.L514W	SK-GT-4	oesophagus	COSMIC	LRSNLGSVV	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.25

Kaplan plot for DHX15 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DHX15

UniProt ID: O43143

Entrez ID: 1665

Protein name: ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15) (Splicing factor Prp43) (hPrp43)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DHX15 in