DegronMD

Uniprot ID: O43143

Source protein: ATP-dependent RNA helicase DHX15

Source gene: DHX15

Class: DEG_APCC_DBOX_1

Location: 503:511

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5468

ASA_SCORE: 25.7444

COIL: 0.2594

CONS_SCORE: 0.7139

DSS_SCORE: 0.1364

HELIX: 0.5774

FCONS_SCORE: 1.1945

RIG_SCORE: 0.8316

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T498I	TCGA-A5-A0G1	UCEC	TCGA	LRSNLGSVV	DEG_APCC_DBOX_1	0.1944
p.T498I	TCGA-CG-4306	STAD	TCGA	LRSNLGSVV	DEG_APCC_DBOX_1	0.1944
p.T498I	DO38567	STAD	ICGC	LRSNLGSVV	DEG_APCC_DBOX_1	0.1944
p.T498I	DO42472	UCEC	ICGC	LRSNLGSVV	DEG_APCC_DBOX_1	0.1944
p.Y499N	TCGA-AN-A0XV	BRCA	TCGA	LRSNLGSVV	DEG_APCC_DBOX_1	0.6667
p.Y499N	DO2913	BRCA	ICGC	LRSNLGSVV	DEG_APCC_DBOX_1	0.6667
p.T498A	TCGA-AX-A1CE	UCEC	TCGA	LRSNLGSVV	DEG_APCC_DBOX_1	0.1944
p.T498A	DO42280	UCEC	ICGC	LRSNLGSVV	DEG_APCC_DBOX_1	0.1944
p.N497K	TCGA-VT-A80G	SARC	TCGA	LRSNLGSVV	DEG_APCC_DBOX_1	0.1667
p.N497K	DO220287	SARC	ICGC	LRSNLGSVV	DEG_APCC_DBOX_1	0.1667
p.D496H	DO223010	ESCA	ICGC	LRSNLGSVV	DEG_APCC_DBOX_1	0.1389
p.D496H	SIDM01617	Endometrial Carcinoma	GDSC	LRSNLGSVV	DEG_APCC_DBOX_1	0.1389
p.Y499C	DO52345	LUSC	ICGC	LRSNLGSVV	DEG_APCC_DBOX_1	0.6667
p.S509L	DO47064	RECA	ICGC	LRSNLGSVV	DEG_APCC_DBOX_1	0.7667
p.L514W	SIDM00483	Esophageal Carcinoma	GDSC	LRSNLGSVV	DEG_APCC_DBOX_1	0.25
p.L514W	ACH-001654	Esophageal Cancer	CCLE	LRSNLGSVV	DEG_APCC_DBOX_1	0.25
p.L514W	SK-GT-4	oesophagus	COSMIC	LRSNLGSVV	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43143	ATP-dependent RNA helicase DHX15	DEG_APCC_DBOX_1	503:511	LRSNLGSVV	APC,CDC20,FZR1	0.5468	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons