DegronMD

Uniprot ID: Q32NC0

Source protein: UPF0711 protein C18orf21

Source gene: C18orf21

Class: DEG_APCC_DBOX_1

Location: 207:215

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9826

ASA_SCORE: 51.2333

COIL: 0.1113

CONS_SCORE: 0.7133

DSS_SCORE: 0.2639

HELIX: 0.8744

FCONS_SCORE: 1.6579

RIG_SCORE: 0.8033

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q200K	TCGA-09-2044	OV	TCGA	FRNFLSSLK	DEG_APCC_DBOX_1	0.1389
p.Q200K	DO28923	OV	ICGC	FRNFLSSLK	DEG_APCC_DBOX_1	0.1389
p.D206N	TCGA-AP-A1DK	UCEC	TCGA	FRNFLSSLK	DEG_APCC_DBOX_1	0.3056
p.D206N	DO42033	UCEC	ICGC	FRNFLSSLK	DEG_APCC_DBOX_1	0.3056
p.L218V	TCGA-B1-A47M	KIRP	TCGA	FRNFLSSLK	DEG_APCC_DBOX_1	0.25
p.L218V	DO49736	KIRP	ICGC	FRNFLSSLK	DEG_APCC_DBOX_1	0.25
p.K201N	TCGA-D1-A103	UCEC	TCGA	FRNFLSSLK	DEG_APCC_DBOX_1	0.2778
p.K201N	DO42312	UCEC	ICGC	FRNFLSSLK	DEG_APCC_DBOX_1	0.2778
p.F210Y	TCGA-D1-A17Q	UCEC	TCGA	FRNFLSSLK	DEG_APCC_DBOX_1	0.6417
p.F210Y	DO41903	UCEC	ICGC	FRNFLSSLK	DEG_APCC_DBOX_1	0.6417
p.N209T	TCGA-F5-6814	READ	TCGA	FRNFLSSLK	DEG_APCC_DBOX_1	0.5944
p.N209T	DO36556	READ	ICGC	FRNFLSSLK	DEG_APCC_DBOX_1	0.5944
p.S213P	TCGA-FS-A1Z3	SKCM	TCGA	FRNFLSSLK	DEG_APCC_DBOX_1	0.6752
p.S213P	DO37635	SKCM	ICGC	FRNFLSSLK	DEG_APCC_DBOX_1	0.6752
p.F210V	DO222798	COCA	ICGC	FRNFLSSLK	DEG_APCC_DBOX_1	0.5957
p.R208G	DO222644	MELA	ICGC	FRNFLSSLK	DEG_APCC_DBOX_1	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q32NC0	UPF0711 protein C18orf21	DEG_APCC_DBOX_1	207:215	FRNFLSSLK	APC,CDC20,FZR1	0.9826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons