DegronMD

Uniprot ID: Q9H0K1

Source protein: Serine/threonine-protein kinase SIK2

Source gene: SIK2

Class: DEG_APCC_DBOX_1

Location: 598:606

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8121

ASA_SCORE: 85.1

COIL: 0.3431

CONS_SCORE: 0.4867

DSS_SCORE: 0.1867

HELIX: 0.6356

FCONS_SCORE: 1.3084

RIG_SCORE: 0.8438

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T608P	TCGA-AA-3715	COAD	TCGA	FRQHLQNLA	DEG_APCC_DBOX_1	0.2778
p.T608P	DO8018	COAD	ICGC	FRQHLQNLA	DEG_APCC_DBOX_1	0.2778
p.R599G	TCGA-AX-A060	UCEC	TCGA	FRQHLQNLA	DEG_APCC_DBOX_1	0.7568
p.R599G	DO42576	UCEC	ICGC	FRQHLQNLA	DEG_APCC_DBOX_1	0.7568
p.I595T	DO6408	CLLE	ICGC	FRQHLQNLA	DEG_APCC_DBOX_1	0.25
p.R607I	DO229026	LICA	ICGC	FRQHLQNLA	DEG_APCC_DBOX_1	0.3056
p.A606S	DO23334	LINC	ICGC	FRQHLQNLA	DEG_APCC_DBOX_1	0.6477
p.Q593E	DO232051	ORCA	ICGC	FRQHLQNLA	DEG_APCC_DBOX_1	0.1944
p.T608S	SIDM00699	Small Cell Lung Carcinoma	GDSC	FRQHLQNLA	DEG_APCC_DBOX_1	0.2778
p.T608S	ACH-001138	Lung Cancer	CCLE	FRQHLQNLA	DEG_APCC_DBOX_1	0.2778
p.T608S	NCI-H2141	lung	COSMIC	FRQHLQNLA	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0K1	Serine/threonine-protein kinase SIK2	DEG_APCC_DBOX_1	598:606	FRQHLQNLA	APC,CDC20,FZR1	0.8121	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons