DegronMD - Q9H0K1(SIK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T608P	TCGA-AA-3715	COAD	TCGA	FRQHLQNLA	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.2778
p.T608P	DO8018	COAD	ICGC	FRQHLQNLA	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.2778
p.R599G	TCGA-AX-A060	UCEC	TCGA	FRQHLQNLA	DEG_APCC_DBOX_1	598:606	Mutation altering degron motif	0.7568
p.R599G	DO42576	UCEC	ICGC	FRQHLQNLA	DEG_APCC_DBOX_1	598:606	Mutation altering degron motif	0.7568
p.R477H	TCGA-D1-A16F	UCEC	TCGA	RRHTLSEVT	DEG_APCC_DBOX_1	481:489	Mutation rewiring degron network	0.2222
p.R477H	TCGA-FI-A2D5	UCEC	TCGA	RRHTLSEVT	DEG_APCC_DBOX_1	481:489	Mutation rewiring degron network	0.2222
p.R477H	DO42408	UCEC	ICGC	RRHTLSEVT	DEG_APCC_DBOX_1	481:489	Mutation rewiring degron network	0.2222
p.R477H	DO41331	UCEC	ICGC	RRHTLSEVT	DEG_APCC_DBOX_1	481:489	Mutation rewiring degron network	0.2222
p.I595T	DO6408	CLLE	ICGC	FRQHLQNLA	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.25
p.R481I	DO229019	LICA	ICGC	RRHTLSEVT	DEG_APCC_DBOX_1	481:489	Mutation altering degron motif	0.6991
p.R607I	DO229026	LICA	ICGC	FRQHLQNLA	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.3056
p.R477L	DO229038	LICA	ICGC	RRHTLSEVT	DEG_APCC_DBOX_1	481:489	Mutation rewiring degron network	0.2222
p.A606S	DO23334	LINC	ICGC	FRQHLQNLA	DEG_APCC_DBOX_1	598:606	Mutation altering degron motif	0.6477
p.Q593E	DO232051	ORCA	ICGC	FRQHLQNLA	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.1944
p.G497W	SIDM01483	Melanoma	GDSC	RRHTLSEVT	DEG_APCC_DBOX_1	481:489	Mutation rewiring degron network	0.1111
p.G497W	ACH-000582	Skin Cancer	CCLE	RRHTLSEVT	DEG_APCC_DBOX_1	481:489	Mutation rewiring degron network	0.1111
p.G497W	COLO-741	large intestine	COSMIC	RRHTLSEVT	DEG_APCC_DBOX_1	481:489	Mutation rewiring degron network	0.1111
p.T608S	SIDM00699	Small Cell Lung Carcinoma	GDSC	FRQHLQNLA	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.2778
p.T608S	ACH-001138	Lung Cancer	CCLE	FRQHLQNLA	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.2778
p.T608S	NCI-H2141	lung	COSMIC	FRQHLQNLA	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.2778
p.N490S	SIDM01608	Endometrial Carcinoma	GDSC	RRHTLSEVT	DEG_APCC_DBOX_1	481:489	Mutation rewiring degron network	0.3056
p.N490S	ACH-000990	Endometrial/Uterine Cancer	CCLE	RRHTLSEVT	DEG_APCC_DBOX_1	481:489	Mutation rewiring degron network	0.3056

Kaplan plot for SIK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SIK2

UniProt ID: Q9H0K1

Entrez ID: 23235

Protein name: Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SIK2 in