DegronMD

Uniprot ID: Q9H0K1

Source protein: Serine/threonine-protein kinase SIK2

Source gene: SIK2

Class: DEG_APCC_DBOX_1

Location: 481:489

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.983

ASA_SCORE: 97.1778

COIL: 0.7643

CONS_SCORE: 0.2545

DSS_SCORE: 0.5149

HELIX: 0.1544

FCONS_SCORE: 0.9612

RIG_SCORE: 0.7278

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R477H	TCGA-D1-A16F	UCEC	TCGA	RRHTLSEVT	DEG_APCC_DBOX_1	0.2222
p.R477H	TCGA-FI-A2D5	UCEC	TCGA	RRHTLSEVT	DEG_APCC_DBOX_1	0.2222
p.R477H	DO42408	UCEC	ICGC	RRHTLSEVT	DEG_APCC_DBOX_1	0.2222
p.R477H	DO41331	UCEC	ICGC	RRHTLSEVT	DEG_APCC_DBOX_1	0.2222
p.R481I	DO229019	LICA	ICGC	RRHTLSEVT	DEG_APCC_DBOX_1	0.6991
p.R477L	DO229038	LICA	ICGC	RRHTLSEVT	DEG_APCC_DBOX_1	0.2222
p.G497W	SIDM01483	Melanoma	GDSC	RRHTLSEVT	DEG_APCC_DBOX_1	0.1111
p.G497W	ACH-000582	Skin Cancer	CCLE	RRHTLSEVT	DEG_APCC_DBOX_1	0.1111
p.G497W	COLO-741	large_intestine	COSMIC	RRHTLSEVT	DEG_APCC_DBOX_1	0.1111
p.N490S	SIDM01608	Endometrial Carcinoma	GDSC	RRHTLSEVT	DEG_APCC_DBOX_1	0.3056
p.N490S	ACH-000990	Endometrial/Uterine Cancer	CCLE	RRHTLSEVT	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0K1	Serine/threonine-protein kinase SIK2	DEG_APCC_DBOX_1	481:489	RRHTLSEVT	APC,CDC20,FZR1	0.983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons