DegronMD

Uniprot ID: P55957

Source protein: BH3-interacting domain death agonist

Source gene: BID

Class: DEG_APCC_DBOX_1

Location: 33:41

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6667

ASA_SCORE: 48.4222

COIL: 0.0561

CONS_SCORE: 0.5628

DSS_SCORE: 0.2035

HELIX: 0.9409

FCONS_SCORE: 1.3455

RIG_SCORE: 0.7918

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E34K	TCGA-70-6722	LUSC	TCGA	FRRELDALG	DEG_APCC_DBOX_1	0.7022
p.E34K	DO27755	LUSC	ICGC	FRRELDALG	DEG_APCC_DBOX_1	0.7022
p.C49Y	TCGA-AA-3492	COAD	TCGA	FRRELDALG	DEG_APCC_DBOX_1	0.1111
p.E50D	TCGA-CQ-6227	HNSC	TCGA	FRRELDALG	DEG_APCC_DBOX_1	0.0833
p.S40R	TCGA-DX-A6YV	SARC	TCGA	FRRELDALG	DEG_APCC_DBOX_1	0.7427
p.R42C	TCGA-FI-A2D0	UCEC	TCGA	FRRELDALG	DEG_APCC_DBOX_1	0.3056
p.R39Q	DO222427	BTCA	ICGC	FRRELDALG	DEG_APCC_DBOX_1	0.7329
p.A39T	DO44440	HNSC	ICGC	FRRELDALG	DEG_APCC_DBOX_1	0.6028
p.D38E	DO229025	LICA	ICGC	FRRELDALG	DEG_APCC_DBOX_1	0.5647
p.P45T	DO229027	LICA	ICGC	FRRELDALG	DEG_APCC_DBOX_1	0.2222
p.P45T	DO229045	LICA	ICGC	FRRELDALG	DEG_APCC_DBOX_1	0.2222
p.E43K	DO36881	READ	ICGC	FRRELDALG	DEG_APCC_DBOX_1	0.2778
p.P49S	DO51298	SKCM	ICGC	FRRELDALG	DEG_APCC_DBOX_1	0.1111
p.L40P	DO219784	UCEC	ICGC	FRRELDALG	DEG_APCC_DBOX_1	0.7582
p.R42H	SIDM00238	Ovarian Carcinoma	GDSC	FRRELDALG	DEG_APCC_DBOX_1	0.3056
p.R42H	OVK-18	ovary	COSMIC	FRRELDALG	DEG_APCC_DBOX_1	0.3056
p.V46A	OVMIU	ovary	COSMIC	FRRELDALG	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55957	BH3-interacting domain death agonist	DEG_APCC_DBOX_1	33:41	FRRELDALG	APC,CDC20,FZR1	0.6667	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons