DegronMD

Uniprot ID: Q8N3Y1

Source protein: F-box/WD repeat-containing protein 8

Source gene: FBXW8

Class: DEG_MDM2_SWIB_1

Location: 9:17

E3 ligase: MDM2

DEGRON score: 0.5123

ASA_SCORE: 68.1667

COIL: 0.0198

CONS_SCORE: 0.5133

DSS_SCORE: 0.4532

HELIX: 0.979

FCONS_SCORE: 1.2428

RIG_SCORE: 0.7877

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K25R	DO228506	BRCA	ICGC	FRRRWQEEL	DEG_MDM2_SWIB_1	0.2222
p.L17M	DO229257	THCA	ICGC	FRRRWQEEL	DEG_MDM2_SWIB_1	0.711
p.A22E	DO229268	THCA	ICGC	FRRRWQEEL	DEG_MDM2_SWIB_1	0.1944
p.R27Q	DO229240	THCA	ICGC	FRRRWQEEL	DEG_MDM2_SWIB_1	0.0556
p.D2Y	ACH-000911	Gastric Cancer	CCLE	FRRRWQEEL	DEG_MDM2_SWIB_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3Y1	F-box/WD repeat-containing protein 8	DEG_MDM2_SWIB_1	9:17	FRRRWQEEL	MDM2	0.5123	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons