DegronMD - Q8N3Y1(FBXW8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R238H	TCGA-A6-2686	COAD	TCGA	VAPFLE	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.1944
p.R238H	TCGA-EO-A22R	UCEC	TCGA	VAPFLE	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.1944
p.S249L	TCGA-CV-A6K2	HNSC	TCGA	VAPFLE	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.3056
p.D251N	TCGA-E7-A5KE	BLCA	TCGA	VAPFLE	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.25
p.E255K	TCGA-G2-A2EO	BLCA	TCGA	VAPFLE	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.1389
p.D233N	DO44029	BLCA	ICGC	VAPFLE	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.0556
p.K25R	DO228506	BRCA	ICGC	FRRRWQEEL	DEG_MDM2_SWIB_1	9:17	Mutation substituting flanking lysine	0.2222
p.V256A	DO233935	GACA	ICGC	VAPFLE	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.1111
p.S242I	DO229009	LICA	ICGC	VAPFLE	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.3056
p.L17M	DO229257	THCA	ICGC	FRRRWQEEL	DEG_MDM2_SWIB_1	9:17	Mutation altering degron motif	0.711
p.A22E	DO229268	THCA	ICGC	FRRRWQEEL	DEG_MDM2_SWIB_1	9:17	Mutation rewiring degron network	0.1944
p.R27Q	DO229240	THCA	ICGC	FRRRWQEEL	DEG_MDM2_SWIB_1	9:17	Mutation rewiring degron network	0.0556
p.D245N	DO41235	UCEC	ICGC	VAPFLE	LIG_APCC_ABBA_1	243:248	Mutation altering degron motif	0.6932
p.R235I	DO41235	UCEC	ICGC	VAPFLE	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.1111
p.D236G	SIDM01307	Colorectal Carcinoma	GDSC	VAPFLE	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.1389
p.E253D	SIDM01080	Oral Cavity Carcinoma	GDSC	VAPFLE	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.1944
p.D2Y	ACH-000911	Gastric Cancer	CCLE	FRRRWQEEL	DEG_MDM2_SWIB_1	9:17	Mutation blocking ubiquitination signal	0.5833
p.A249T	GP5d	large intestine	COSMIC	VAPFLE	LIG_APCC_ABBA_1	243:248	Mutation rewiring degron network	0.3056

Kaplan plot for FBXW8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FBXW8

UniProt ID: Q8N3Y1

Entrez ID: 26259

Protein name: F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FBXW8 in