DegronMD

Uniprot ID: Q8N3Y1

Source protein: F-box/WD repeat-containing protein 8

Source gene: FBXW8

Class: LIG_APCC_ABBA_1

Location: 243:248

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.934

ASA_SCORE: 63.7333

COIL: 0.3772

CONS_SCORE: 0.3319

DSS_SCORE: 0.3964

HELIX: 0.0218

FCONS_SCORE: 0.7612

RIG_SCORE: 0.8641

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R238H	TCGA-A6-2686	COAD	TCGA	VAPFLE	LIG_APCC_ABBA_1	0.1944
p.R238H	TCGA-EO-A22R	UCEC	TCGA	VAPFLE	LIG_APCC_ABBA_1	0.1944
p.S249L	TCGA-CV-A6K2	HNSC	TCGA	VAPFLE	LIG_APCC_ABBA_1	0.3056
p.D251N	TCGA-E7-A5KE	BLCA	TCGA	VAPFLE	LIG_APCC_ABBA_1	0.25
p.E255K	TCGA-G2-A2EO	BLCA	TCGA	VAPFLE	LIG_APCC_ABBA_1	0.1389
p.D233N	DO44029	BLCA	ICGC	VAPFLE	LIG_APCC_ABBA_1	0.0556
p.V256A	DO233935	GACA	ICGC	VAPFLE	LIG_APCC_ABBA_1	0.1111
p.S242I	DO229009	LICA	ICGC	VAPFLE	LIG_APCC_ABBA_1	0.3056
p.D245N	DO41235	UCEC	ICGC	VAPFLE	LIG_APCC_ABBA_1	0.6932
p.R235I	DO41235	UCEC	ICGC	VAPFLE	LIG_APCC_ABBA_1	0.1111
p.D236G	SIDM01307	Colorectal Carcinoma	GDSC	VAPFLE	LIG_APCC_ABBA_1	0.1389
p.E253D	SIDM01080	Oral Cavity Carcinoma	GDSC	VAPFLE	LIG_APCC_ABBA_1	0.1944
p.A249T	GP5d	large_intestine	COSMIC	VAPFLE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3Y1	F-box/WD repeat-containing protein 8	LIG_APCC_ABBA_1	243:248	VAPFLE	APC,CDC20,FZR1	0.934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons