DegronMD

Uniprot ID: O95239

Source protein: Chromosome-associated kinesin KIF4A

Source gene: KIF4A

Class: DEG_APCC_DBOX_1

Location: 232:240

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6615

ASA_SCORE: 40.0556

COIL: 0.1559

CONS_SCORE: 0.6405

DSS_SCORE: 0.4425

HELIX: 0.0289

FCONS_SCORE: 1.1218

RIG_SCORE: 0.7533

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R223T	TCGA-17-Z028	LUAD	TCGA	FRSKLHLVD	DEG_APCC_DBOX_1	0.0833
p.G243V	TCGA-30-1718	OV	TCGA	FRSKLHLVD	DEG_APCC_DBOX_1	0.25
p.G243V	DO32708	OV	ICGC	FRSKLHLVD	DEG_APCC_DBOX_1	0.25
p.T250I	TCGA-5M-AAT6	COAD	TCGA	FRSKLHLVD	DEG_APCC_DBOX_1	0.0556
p.T250I	DO223703	COAD	ICGC	FRSKLHLVD	DEG_APCC_DBOX_1	0.0556
p.R233C	DO230343	COCA	ICGC	FRSKLHLVD	DEG_APCC_DBOX_1	0.8301
p.R233H	DO229039	LICA	ICGC	FRSKLHLVD	DEG_APCC_DBOX_1	0.8244
p.K224N	ACH-001864	Bile Duct Cancer	CCLE	FRSKLHLVD	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95239	Chromosome-associated kinesin KIF4A	DEG_APCC_DBOX_1	232:240	FRSKLHLVD	APC,CDC20,FZR1	0.6615	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons