DegronMD - O95239(KIF4A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R223T	TCGA-17-Z028	LUAD	TCGA	FRSKLHLVD	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.0833
p.G243V	TCGA-30-1718	OV	TCGA	FRSKLHLVD	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.25
p.G243V	DO32708	OV	ICGC	FRSKLHLVD	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.25
p.G1151E	TCGA-49-AARN	LUAD	TCGA	VTPGLS	DEG_SCF_FBW7_1	1148:1153	Mutation altering degron motif	0.6087
p.G1151E	DO218923	LUAD	ICGC	VTPGLS	DEG_SCF_FBW7_1	1148:1153	Mutation altering degron motif	0.6087
p.T250I	TCGA-5M-AAT6	COAD	TCGA	FRSKLHLVD	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.0556
p.T250I	DO223703	COAD	ICGC	FRSKLHLVD	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.0556
p.D588N	TCGA-A8-A08R	BRCA	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.0556
p.D588N	DO1255	BRCA	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.0556
p.R289I	TCGA-AJ-A3EL	UCEC	TCGA	FVPYRD	LIG_APCC_ABBA_1	285:290	Mutation altering degron motif	0.6991
p.R289I	DO41542	UCEC	ICGC	FVPYRD	LIG_APCC_ABBA_1	285:290	Mutation altering degron motif	0.6991
p.E606Q	TCGA-AJ-A3EL	UCEC	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation altering degron motif	0.5633
p.E606Q	DO41542	UCEC	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation altering degron motif	0.5633
p.V1158I	TCGA-AR-A24S	BRCA	TCGA	VTPGLS	DEG_SCF_FBW7_1	1148:1153	Mutation rewiring degron network	0.1944
p.V1158I	DO1414	BRCA	ICGC	VTPGLS	DEG_SCF_FBW7_1	1148:1153	Mutation rewiring degron network	0.1944
p.K614N	TCGA-AX-A05Z	UCEC	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation substituting flanking lysine	0.2222
p.K614N	DO40884	UCEC	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation substituting flanking lysine	0.2222
p.N1163I	TCGA-AX-A063	UCEC	TCGA	VTPGLS	DEG_SCF_FBW7_1	1148:1153	Mutation rewiring degron network	0.0556
p.N1163I	DO42201	UCEC	ICGC	VTPGLS	DEG_SCF_FBW7_1	1148:1153	Mutation rewiring degron network	0.0556
p.R597C	TCGA-AX-A0J0	UCEC	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.3056
p.R597C	TCGA-BS-A0UF	UCEC	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.3056
p.R597C	TCGA-D1-A2G0	UCEC	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.3056
p.R597C	DO43049	UCEC	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.3056
p.R597C	DO41133	UCEC	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.3056
p.R597C	DO41488	UCEC	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.3056
p.E1147K	TCGA-B5-A0JY	UCEC	TCGA	VTPGLS	DEG_SCF_FBW7_1	1148:1153	Mutation rewiring degron network	0.3056
p.E1147K	DO43041	UCEC	ICGC	VTPGLS	DEG_SCF_FBW7_1	1148:1153	Mutation rewiring degron network	0.3056
p.N590S	TCGA-B5-A3FA	UCEC	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.1111
p.N590S	DO52402	UCEC	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.1111
p.S1153G	TCGA-BS-A0UL	UCEC	TCGA	VTPGLS	DEG_SCF_FBW7_1	1148:1153	Mutation altering degron motif	0.6993
p.S1153G	DO41319	UCEC	ICGC	VTPGLS	DEG_SCF_FBW7_1	1148:1153	Mutation altering degron motif	0.6993
p.R599H	TCGA-DW-7838	KIRP	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation altering degron motif	0.8244
p.R599H	DO20815	KIRP	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation altering degron motif	0.8244
p.P1157L	TCGA-EB-A431	SKCM	TCGA	VTPGLS	DEG_SCF_FBW7_1	1148:1153	Mutation rewiring degron network	0.2222
p.P1157L	DO37671	SKCM	ICGC	VTPGLS	DEG_SCF_FBW7_1	1148:1153	Mutation rewiring degron network	0.2222
p.A276V	TCGA-EO-A3B0	UCEC	TCGA	FVPYRD	LIG_APCC_ABBA_1	285:290	Mutation rewiring degron network	0.0833
p.A276V	DO219773	UCEC	ICGC	FVPYRD	LIG_APCC_ABBA_1	285:290	Mutation rewiring degron network	0.0833
p.K292T	TCGA-F4-6570	COAD	TCGA	FVPYRD	LIG_APCC_ABBA_1	285:290	Mutation blocking ubiquitination signal	0.7222
p.K292T	DO10443	COAD	ICGC	FVPYRD	LIG_APCC_ABBA_1	285:290	Mutation blocking ubiquitination signal	0.7222
p.L602I	TCGA-FU-A3HZ	CESC	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation altering degron motif	0.7174
p.L602I	DO6308	CESC	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation altering degron motif	0.7174
p.R295G	TCGA-GC-A6I3	BLCA	TCGA	FVPYRD	LIG_APCC_ABBA_1	285:290	Mutation rewiring degron network	0.1944
p.R295G	DO219025	BLCA	ICGC	FVPYRD	LIG_APCC_ABBA_1	285:290	Mutation rewiring degron network	0.1944
p.R601C	TCGA-KN-8428	KICH	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation altering degron motif	0.719
p.R601C	DO220484	KICH	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation altering degron motif	0.719
p.Q591H	TCGA-LN-A4A1	ESCA	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.1389
p.K600R	TCGA-MI-A75I	LIHC	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation altering degron motif	0.6126
p.K600R	DO49712	LIHC	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation altering degron motif	0.6126
p.D280Y	TCGA-UY-A78N	BLCA	TCGA	FVPYRD	LIG_APCC_ABBA_1	285:290	Mutation rewiring degron network	0.1944
p.D280Y	DO219034	BLCA	ICGC	FVPYRD	LIG_APCC_ABBA_1	285:290	Mutation rewiring degron network	0.1944
p.L612M	TCGA-UY-A78N	BLCA	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.1667
p.L612M	DO219034	BLCA	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.1667
p.R233C	DO230343	COCA	ICGC	FRSKLHLVD	DEG_APCC_DBOX_1	232:240	Mutation altering degron motif	0.8301
p.L594F	DO52492	COCA	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.2222
p.L594F	DO228986	LICA	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.2222
p.E606D	DO228952	LICA	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation altering degron motif	0.5647
p.K282N	DO229026	LICA	ICGC	FVPYRD	LIG_APCC_ABBA_1	285:290	Mutation substituting flanking lysine	0.3611
p.R233H	DO229039	LICA	ICGC	FRSKLHLVD	DEG_APCC_DBOX_1	232:240	Mutation altering degron motif	0.8244
p.R598L	DO23428	LINC	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation altering degron motif	0.7316
p.G1138D	DO222504	MELA	ICGC	VTPGLS	DEG_SCF_FBW7_1	1148:1153	Mutation rewiring degron network	0.0556
p.S595I	DO229216	THCA	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.25
p.D588G	SIDM01259	B-Lymphoblastic Leukemia	GDSC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.0556
p.D588G	ACH-001669	Leukemia	CCLE	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.0556
p.D588G	ACH-002238	Leukemia	CCLE	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.0556
p.D588G	GR-ST	haematopoietic and lymphoid tissue	COSMIC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.0556
p.R597H	SIDM01728	Endometrial Carcinoma	GDSC	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.3056
p.R597H	ACH-000173	Endometrial/Uterine Cancer	CCLE	RRKRLQELE	DEG_APCC_DBOX_1	598:606	Mutation rewiring degron network	0.3056
p.K224N	ACH-001864	Bile Duct Cancer	CCLE	FRSKLHLVD	DEG_APCC_DBOX_1	232:240	Mutation substituting flanking lysine	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF4A

UniProt ID: O95239

Entrez ID: 24137

Protein name: Chromosome-associated kinesin KIF4A (Chromokinesin-A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF4A in