DegronMD

Uniprot ID: O95239

Source protein: Chromosome-associated kinesin KIF4A

Source gene: KIF4A

Class: LIG_APCC_ABBA_1

Location: 285:290

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8086

ASA_SCORE: 62.9667

COIL: 0.7075

CONS_SCORE: 0.6567

DSS_SCORE: 0.2816

HELIX: 0.2165

FCONS_SCORE: 0.9847

RIG_SCORE: 0.8309

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R289I	TCGA-AJ-A3EL	UCEC	TCGA	FVPYRD	LIG_APCC_ABBA_1	0.6991
p.R289I	DO41542	UCEC	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.6991
p.A276V	TCGA-EO-A3B0	UCEC	TCGA	FVPYRD	LIG_APCC_ABBA_1	0.0833
p.A276V	DO219773	UCEC	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.0833
p.K292T	TCGA-F4-6570	COAD	TCGA	FVPYRD	LIG_APCC_ABBA_1	0.7222
p.K292T	DO10443	COAD	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.7222
p.R295G	TCGA-GC-A6I3	BLCA	TCGA	FVPYRD	LIG_APCC_ABBA_1	0.1944
p.R295G	DO219025	BLCA	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.1944
p.D280Y	TCGA-UY-A78N	BLCA	TCGA	FVPYRD	LIG_APCC_ABBA_1	0.1944
p.D280Y	DO219034	BLCA	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.1944
p.K282N	DO229026	LICA	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.3611

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95239	Chromosome-associated kinesin KIF4A	LIG_APCC_ABBA_1	285:290	FVPYRD	APC,CDC20,FZR1	0.8086	More...
Q96L93	Kinesin-like protein KIF16B	LIG_APCC_ABBA_1	307:312	FVPYRD	APC,CDC20,FZR1	0.814	More...
Q9NQT8	Kinesin-like protein KIF13B	LIG_APCC_ABBA_1	302:307	FVPYRD	APC,CDC20,FZR1	0.6264	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons