DegronMD

Uniprot ID: Q96L93

Source protein: Kinesin-like protein KIF16B

Source gene: KIF16B

Class: LIG_APCC_ABBA_1

Location: 307:312

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.814

ASA_SCORE: 46.2333

COIL: 0.5707

CONS_SCORE: 0.7715

DSS_SCORE: 0.0636

HELIX: 0.3548

FCONS_SCORE: 1.3186

RIG_SCORE: 0.8988

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K304M	TCGA-2Z-A9JL	KIRP	TCGA	FVPYRD	LIG_APCC_ABBA_1	0.3611
p.K304M	DO219675	KIRP	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.3611
p.V308M	TCGA-A6-6653	COAD	TCGA	FVPYRD	LIG_APCC_ABBA_1	0.6097
p.V308M	DO10373	COAD	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.6097
p.V308M	DO220856	MELA	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.6097
p.K303N	TCGA-AX-A06F	UCEC	TCGA	FVPYRD	LIG_APCC_ABBA_1	0.3333
p.K303N	DO41752	UCEC	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.3333
p.R311S	TCGA-D9-A148	SKCM	TCGA	FVPYRD	LIG_APCC_ABBA_1	0.6316
p.R311S	DO37971	SKCM	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.6316
p.R311M	TCGA-EE-A2GT	SKCM	TCGA	FVPYRD	LIG_APCC_ABBA_1	0.7521
p.R311M	TCGA-ER-A19B	SKCM	TCGA	FVPYRD	LIG_APCC_ABBA_1	0.7521
p.R311M	DO47491	SKCM	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.7521
p.R311M	DO37946	SKCM	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.7521
p.N298D	SIDM00156	Neuroblastoma	GDSC	FVPYRD	LIG_APCC_ABBA_1	0.0833
p.N298D	ACH-002285	Neuroblastoma	CCLE	FVPYRD	LIG_APCC_ABBA_1	0.0833
p.N298D	NB7	autonomic_ganglia	COSMIC	FVPYRD	LIG_APCC_ABBA_1	0.0833
p.A301S	SIDM00292	Small Cell Lung Carcinoma	GDSC	FVPYRD	LIG_APCC_ABBA_1	0.1667
p.A301S	ACH-002077	Lung Cancer	CCLE	FVPYRD	LIG_APCC_ABBA_1	0.1667
p.A301S	LU-165	lung	COSMIC	FVPYRD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95239	Chromosome-associated kinesin KIF4A	LIG_APCC_ABBA_1	285:290	FVPYRD	APC,CDC20,FZR1	0.8086	More...
Q96L93	Kinesin-like protein KIF16B	LIG_APCC_ABBA_1	307:312	FVPYRD	APC,CDC20,FZR1	0.814	More...
Q9NQT8	Kinesin-like protein KIF13B	LIG_APCC_ABBA_1	302:307	FVPYRD	APC,CDC20,FZR1	0.6264	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons