DegronMD

Uniprot ID: Q9NQT8

Source protein: Kinesin-like protein KIF13B

Source gene: KIF13B

Class: LIG_APCC_ABBA_1

Location: 302:307

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6264

ASA_SCORE: 45.5333

COIL: 0.5742

CONS_SCORE: 0.7854

DSS_SCORE: 0.1899

HELIX: 0.2867

FCONS_SCORE: 1.2408

RIG_SCORE: 0.8689

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D292G	TCGA-34-7107	LUSC	TCGA	FVPYRD	LIG_APCC_ABBA_1	0.0556
p.D292G	DO26449	LUSC	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.0556
p.K299N	TCGA-AG-A002	READ	TCGA	FVPYRD	LIG_APCC_ABBA_1	0.3611
p.K299N	TCGA-F5-6814	READ	TCGA	FVPYRD	LIG_APCC_ABBA_1	0.3611
p.K299N	DO36556	READ	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.3611
p.P304A	TCGA-BK-A0C9	UCEC	TCGA	FVPYRD	LIG_APCC_ABBA_1	0.7503
p.P304A	DO41253	UCEC	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.7503
p.K301N	TCGA-CA-6717	COAD	TCGA	FVPYRD	LIG_APCC_ABBA_1	0.3056
p.K301N	DO8264	COAD	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.3056
p.N300H	TCGA-EO-A22U	UCEC	TCGA	FVPYRD	LIG_APCC_ABBA_1	0.2778
p.N300H	DO43755	UCEC	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.2778
p.P304L	TCGA-ER-A19F	SKCM	TCGA	FVPYRD	LIG_APCC_ABBA_1	0.6471
p.P304L	DO37679	SKCM	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.6471
p.R306C	TCGA-ER-A2NE	SKCM	TCGA	FVPYRD	LIG_APCC_ABBA_1	0.719
p.R306C	DO233884	GACA	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.719
p.R306C	DO233823	GACA	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.719
p.R306C	DO48663	SKCM	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.719
p.R306H	DO233652	GACA	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.7133
p.A295D	DO229036	LICA	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.1389
p.D316E	DO229054	LICA	ICGC	FVPYRD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95239	Chromosome-associated kinesin KIF4A	LIG_APCC_ABBA_1	285:290	FVPYRD	APC,CDC20,FZR1	0.8086	More...
Q96L93	Kinesin-like protein KIF16B	LIG_APCC_ABBA_1	307:312	FVPYRD	APC,CDC20,FZR1	0.814	More...
Q9NQT8	Kinesin-like protein KIF13B	LIG_APCC_ABBA_1	302:307	FVPYRD	APC,CDC20,FZR1	0.6264	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons