DegronMD - Q9NQT8(KIF13B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D292G	TCGA-34-7107	LUSC	TCGA	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation rewiring degron network	0.0556
p.D292G	DO26449	LUSC	ICGC	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation rewiring degron network	0.0556
p.K299N	TCGA-AG-A002	READ	TCGA	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation substituting flanking lysine	0.3611
p.K299N	TCGA-F5-6814	READ	TCGA	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation substituting flanking lysine	0.3611
p.K299N	DO36556	READ	ICGC	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation substituting flanking lysine	0.3611
p.P304A	TCGA-BK-A0C9	UCEC	TCGA	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation altering degron motif	0.7503
p.P304A	DO41253	UCEC	ICGC	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation altering degron motif	0.7503
p.K301N	TCGA-CA-6717	COAD	TCGA	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation rewiring degron network	0.3056
p.K301N	DO8264	COAD	ICGC	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation rewiring degron network	0.3056
p.P1557S	TCGA-D5-6540	COAD	TCGA	VTPAPE	DEG_SCF_FBW7_2	1547:1552	Mutation rewiring degron network	0.1944
p.P1557S	DO9708	COAD	ICGC	VTPAPE	DEG_SCF_FBW7_2	1547:1552	Mutation rewiring degron network	0.1944
p.V1544I	TCGA-EC-A24G	UCEC	TCGA	VTPAPE	DEG_SCF_FBW7_2	1547:1552	Mutation rewiring degron network	0.25
p.V1544I	DO40996	UCEC	ICGC	VTPAPE	DEG_SCF_FBW7_2	1547:1552	Mutation rewiring degron network	0.25
p.N300H	TCGA-EO-A22U	UCEC	TCGA	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation rewiring degron network	0.2778
p.N300H	DO43755	UCEC	ICGC	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation rewiring degron network	0.2778
p.P304L	TCGA-ER-A19F	SKCM	TCGA	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation altering degron motif	0.6471
p.P304L	DO37679	SKCM	ICGC	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation altering degron motif	0.6471
p.R306C	TCGA-ER-A2NE	SKCM	TCGA	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation altering degron motif	0.719
p.R306C	DO233884	GACA	ICGC	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation altering degron motif	0.719
p.R306C	DO233823	GACA	ICGC	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation altering degron motif	0.719
p.R306C	DO48663	SKCM	ICGC	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation altering degron motif	0.719
p.V1547A	DO233634	GACA	ICGC	VTPAPE	DEG_SCF_FBW7_2	1547:1552	Mutation altering degron motif	0.6936
p.R306H	DO233652	GACA	ICGC	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation altering degron motif	0.7133
p.A295D	DO229036	LICA	ICGC	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation rewiring degron network	0.1389
p.D316E	DO229054	LICA	ICGC	FVPYRD	LIG_APCC_ABBA_1	302:307	Mutation rewiring degron network	0.0833
p.A1553E	DO229201	THCA	ICGC	VTPAPE	DEG_SCF_FBW7_2	1547:1552	Mutation rewiring degron network	0.3056
p.V1544A	DO229240	THCA	ICGC	VTPAPE	DEG_SCF_FBW7_2	1547:1552	Mutation rewiring degron network	0.25
p.S1537Y	DO229242	THCA	ICGC	VTPAPE	DEG_SCF_FBW7_2	1547:1552	Mutation blocking phosphorylation signal	0.5
p.A1553V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VTPAPE	DEG_SCF_FBW7_2	1547:1552	Mutation rewiring degron network	0.3056
p.A1553V	ACH-002256	Leukemia	CCLE	VTPAPE	DEG_SCF_FBW7_2	1547:1552	Mutation rewiring degron network	0.3056
p.A1553V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VTPAPE	DEG_SCF_FBW7_2	1547:1552	Mutation rewiring degron network	0.3056

Kaplan plot for KIF13B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF13B

UniProt ID: Q9NQT8

Entrez ID: 23303

Protein name: Kinesin-like protein KIF13B (Kinesin-like protein GAKIN)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF13B in