DegronMD

Uniprot ID: Q9NQT8

Source protein: Kinesin-like protein KIF13B

Source gene: KIF13B

Class: DEG_SCF_FBW7_2

Location: 1547:1552

E3 ligase: FBXW7

DEGRON score: 0.9893

ASA_SCORE: 96.1667

COIL: 0.9567

CONS_SCORE: 0.2393

DSS_SCORE: 0.565

HELIX: 0.025

FCONS_SCORE: 0.9313

RIG_SCORE: 0.6879

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1557S	TCGA-D5-6540	COAD	TCGA	VTPAPE	DEG_SCF_FBW7_2	0.1944
p.P1557S	DO9708	COAD	ICGC	VTPAPE	DEG_SCF_FBW7_2	0.1944
p.V1544I	TCGA-EC-A24G	UCEC	TCGA	VTPAPE	DEG_SCF_FBW7_2	0.25
p.V1544I	DO40996	UCEC	ICGC	VTPAPE	DEG_SCF_FBW7_2	0.25
p.V1547A	DO233634	GACA	ICGC	VTPAPE	DEG_SCF_FBW7_2	0.6936
p.A1553E	DO229201	THCA	ICGC	VTPAPE	DEG_SCF_FBW7_2	0.3056
p.V1544A	DO229240	THCA	ICGC	VTPAPE	DEG_SCF_FBW7_2	0.25
p.S1537Y	DO229242	THCA	ICGC	VTPAPE	DEG_SCF_FBW7_2	0.5
p.A1553V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VTPAPE	DEG_SCF_FBW7_2	0.3056
p.A1553V	ACH-002256	Leukemia	CCLE	VTPAPE	DEG_SCF_FBW7_2	0.3056
p.A1553V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VTPAPE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQT8	Kinesin-like protein KIF13B	DEG_SCF_FBW7_2	1547:1552	VTPAPE	FBXW7	0.9893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons