DegronMD

Uniprot ID: O95239

Source protein: Chromosome-associated kinesin KIF4A

Source gene: KIF4A

Class: DEG_APCC_DBOX_1

Location: 598:606

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7386

ASA_SCORE: 117.4333

COIL: 0.0457

CONS_SCORE: 0.4496

DSS_SCORE: 0.3969

HELIX: 0.9577

FCONS_SCORE: 1.2152

RIG_SCORE: 0.7471

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D588N	TCGA-A8-A08R	BRCA	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	0.0556
p.D588N	DO1255	BRCA	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	0.0556
p.E606Q	TCGA-AJ-A3EL	UCEC	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	0.5633
p.E606Q	DO41542	UCEC	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	0.5633
p.K614N	TCGA-AX-A05Z	UCEC	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	0.2222
p.K614N	DO40884	UCEC	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	0.2222
p.R597C	TCGA-AX-A0J0	UCEC	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	0.3056
p.R597C	TCGA-BS-A0UF	UCEC	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	0.3056
p.R597C	TCGA-D1-A2G0	UCEC	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	0.3056
p.R597C	DO43049	UCEC	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	0.3056
p.R597C	DO41133	UCEC	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	0.3056
p.R597C	DO41488	UCEC	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	0.3056
p.N590S	TCGA-B5-A3FA	UCEC	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	0.1111
p.N590S	DO52402	UCEC	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	0.1111
p.R599H	TCGA-DW-7838	KIRP	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	0.8244
p.R599H	DO20815	KIRP	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	0.8244
p.L602I	TCGA-FU-A3HZ	CESC	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	0.7174
p.L602I	DO6308	CESC	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	0.7174
p.R601C	TCGA-KN-8428	KICH	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	0.719
p.R601C	DO220484	KICH	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	0.719
p.Q591H	TCGA-LN-A4A1	ESCA	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	0.1389
p.K600R	TCGA-MI-A75I	LIHC	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	0.6126
p.K600R	DO49712	LIHC	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	0.6126
p.L612M	TCGA-UY-A78N	BLCA	TCGA	RRKRLQELE	DEG_APCC_DBOX_1	0.1667
p.L612M	DO219034	BLCA	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	0.1667
p.L594F	DO52492	COCA	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	0.2222
p.L594F	DO228986	LICA	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	0.2222
p.E606D	DO228952	LICA	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	0.5647
p.R598L	DO23428	LINC	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	0.7316
p.S595I	DO229216	THCA	ICGC	RRKRLQELE	DEG_APCC_DBOX_1	0.25
p.D588G	SIDM01259	B-Lymphoblastic Leukemia	GDSC	RRKRLQELE	DEG_APCC_DBOX_1	0.0556
p.D588G	ACH-001669	Leukemia	CCLE	RRKRLQELE	DEG_APCC_DBOX_1	0.0556
p.D588G	ACH-002238	Leukemia	CCLE	RRKRLQELE	DEG_APCC_DBOX_1	0.0556
p.D588G	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	RRKRLQELE	DEG_APCC_DBOX_1	0.0556
p.R597H	SIDM01728	Endometrial Carcinoma	GDSC	RRKRLQELE	DEG_APCC_DBOX_1	0.3056
p.R597H	ACH-000173	Endometrial/Uterine Cancer	CCLE	RRKRLQELE	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRKRLQELE

Degron related mutations and impact score

Drug responses associated with KIF4A mutations

All proteins holding degron of RRKRLQELE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95239	Chromosome-associated kinesin KIF4A	DEG_APCC_DBOX_1	598:606	RRKRLQELE	APC,CDC20,FZR1	0.7386	More...