DegronMD

Uniprot ID: O95239

Source protein: Chromosome-associated kinesin KIF4A

Source gene: KIF4A

Class: DEG_SCF_FBW7_1

Location: 1148:1153

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 68.3833

COIL: 0.8387

CONS_SCORE: 0.3373

DSS_SCORE: 0.375

HELIX: 0.042

FCONS_SCORE: 0.9844

RIG_SCORE: 0.751

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1151E	TCGA-49-AARN	LUAD	TCGA	VTPGLS	DEG_SCF_FBW7_1	0.6087
p.G1151E	DO218923	LUAD	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.6087
p.V1158I	TCGA-AR-A24S	BRCA	TCGA	VTPGLS	DEG_SCF_FBW7_1	0.1944
p.V1158I	DO1414	BRCA	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.1944
p.N1163I	TCGA-AX-A063	UCEC	TCGA	VTPGLS	DEG_SCF_FBW7_1	0.0556
p.N1163I	DO42201	UCEC	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.0556
p.E1147K	TCGA-B5-A0JY	UCEC	TCGA	VTPGLS	DEG_SCF_FBW7_1	0.3056
p.E1147K	DO43041	UCEC	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.3056
p.S1153G	TCGA-BS-A0UL	UCEC	TCGA	VTPGLS	DEG_SCF_FBW7_1	0.6993
p.S1153G	DO41319	UCEC	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.6993
p.P1157L	TCGA-EB-A431	SKCM	TCGA	VTPGLS	DEG_SCF_FBW7_1	0.2222
p.P1157L	DO37671	SKCM	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.2222
p.G1138D	DO222504	MELA	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95239	Chromosome-associated kinesin KIF4A	DEG_SCF_FBW7_1	1148:1153	VTPGLS	FBXW7	0.999	More...
Q2VIQ3	Chromosome-associated kinesin KIF4B	DEG_SCF_FBW7_1	1150:1155	VTPGLS	FBXW7	0.9954	More...
Q9NQH7	Xaa-Pro aminopeptidase 3	DEG_SCF_FBW7_1	63:68	VTPGLS	FBXW7	0.9621	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons