DegronMD

Uniprot ID: Q9NQH7

Source protein: Xaa-Pro aminopeptidase 3

Source gene: XPNPEP3

Class: DEG_SCF_FBW7_1

Location: 63:68

E3 ligase: FBXW7

DEGRON score: 0.9621

ASA_SCORE: 44.75

COIL: 0.8398

CONS_SCORE: 0.3953

DSS_SCORE: 0.4242

HELIX: 0.0148

FCONS_SCORE: 1.0177

RIG_SCORE: 0.6997

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R59T	TCGA-66-2773	LUSC	TCGA	VTPGLS	DEG_SCF_FBW7_1	0.2222
p.R75H	TCGA-AA-3510	COAD	TCGA	VTPGLS	DEG_SCF_FBW7_1	0.1389
p.R75H	SIDM01551	Gastric Carcinoma	GDSC	VTPGLS	DEG_SCF_FBW7_1	0.1389
p.R75H	ACH-000485	Gastric Cancer	CCLE	VTPGLS	DEG_SCF_FBW7_1	0.1389
p.P55S	TCGA-CV-7242	HNSC	TCGA	VTPGLS	DEG_SCF_FBW7_1	0.1111
p.Q72H	DO1080	BRCA	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.2222
p.L59M	DO10880	GBM	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.2222
p.G66W	DO228952	LICA	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.6714
p.S68R	DO45259	LIRI	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.7427
p.V75A	DO51783	STAD	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.1389
p.L67P	SIDM01314	Colorectal Carcinoma	GDSC	VTPGLS	DEG_SCF_FBW7_1	0.6471
p.R75G	SIDM00523	Small Cell Lung Carcinoma	GDSC	VTPGLS	DEG_SCF_FBW7_1	0.1389
p.R75G	ACH-000698	Lung Cancer	CCLE	VTPGLS	DEG_SCF_FBW7_1	0.1389
p.R75G	DMS-53	lung	COSMIC	VTPGLS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95239	Chromosome-associated kinesin KIF4A	DEG_SCF_FBW7_1	1148:1153	VTPGLS	FBXW7	0.999	More...
Q2VIQ3	Chromosome-associated kinesin KIF4B	DEG_SCF_FBW7_1	1150:1155	VTPGLS	FBXW7	0.9954	More...
Q9NQH7	Xaa-Pro aminopeptidase 3	DEG_SCF_FBW7_1	63:68	VTPGLS	FBXW7	0.9621	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons