DegronMD

Uniprot ID: Q2VIQ3

Source protein: Chromosome-associated kinesin KIF4B

Source gene: KIF4B

Class: DEG_SCF_FBW7_1

Location: 1150:1155

E3 ligase: FBXW7

DEGRON score: 0.9954

ASA_SCORE: 66.0833

COIL: 0.741

CONS_SCORE: 0.3291

DSS_SCORE: 0.3929

HELIX: 0.0512

FCONS_SCORE: 1.0153

RIG_SCORE: 0.7457

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1153V	TCGA-AA-A010	COAD	TCGA	VTPGLS	DEG_SCF_FBW7_1	0.6421
p.P1159S	TCGA-AA-A01P	COAD	TCGA	VTPGLS	DEG_SCF_FBW7_1	0.2222
p.P1159S	DO8642	COAD	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.2222
p.A1162S	TCGA-B5-A1MU	UCEC	TCGA	VTPGLS	DEG_SCF_FBW7_1	0.1389
p.A1162S	DO41512	UCEC	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.1389
p.G1140S	TCGA-DA-A95W	SKCM	TCGA	VTPGLS	DEG_SCF_FBW7_1	0.0556
p.G1140S	DO219479	SKCM	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.0556
p.P1147S	TCGA-EB-A44O	SKCM	TCGA	VTPGLS	DEG_SCF_FBW7_1	0.25
p.P1147S	TCGA-FW-A3R5	SKCM	TCGA	VTPGLS	DEG_SCF_FBW7_1	0.25
p.P1147S	DO47272	SKCM	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.25
p.P1147S	DO37406	SKCM	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.25
p.L1154F	TCGA-EE-A29X	SKCM	TCGA	VTPGLS	DEG_SCF_FBW7_1	0.587
p.L1154F	DO37595	SKCM	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.587
p.G1153E	TCGA-ER-A3PL	SKCM	TCGA	VTPGLS	DEG_SCF_FBW7_1	0.6087
p.G1153E	DO8264	COAD	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.6087
p.G1153E	DO37495	SKCM	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.6087
p.S1141F	TCGA-GN-A4U4	SKCM	TCGA	VTPGLS	DEG_SCF_FBW7_1	0.5278
p.S1141F	DO51256	SKCM	ICGC	VTPGLS	DEG_SCF_FBW7_1	0.5278
p.F1156S	SIDM00157	Neuroblastoma	GDSC	VTPGLS	DEG_SCF_FBW7_1	0.3056
p.F1156S	ACH-002261	Neuroblastoma	CCLE	VTPGLS	DEG_SCF_FBW7_1	0.3056
p.F1156S	KP-N-YS	autonomic_ganglia	COSMIC	VTPGLS	DEG_SCF_FBW7_1	0.3056
p.P1152Q	SIDM01739	Small Cell Lung Carcinoma	GDSC	VTPGLS	DEG_SCF_FBW7_1	0.7035
p.P1152Q	ACH-000297	Lung Cancer	CCLE	VTPGLS	DEG_SCF_FBW7_1	0.7035

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95239	Chromosome-associated kinesin KIF4A	DEG_SCF_FBW7_1	1148:1153	VTPGLS	FBXW7	0.999	More...
Q2VIQ3	Chromosome-associated kinesin KIF4B	DEG_SCF_FBW7_1	1150:1155	VTPGLS	FBXW7	0.9954	More...
Q9NQH7	Xaa-Pro aminopeptidase 3	DEG_SCF_FBW7_1	63:68	VTPGLS	FBXW7	0.9621	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons