DegronMD - Q2VIQ3(KIF4B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R156L	TCGA-60-2698	LUSC	TCGA	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.0556
p.R156L	DO26469	LUSC	ICGC	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.0556
p.D131G	TCGA-A5-A0GP	UCEC	TCGA	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.0556
p.D131G	DO41109	UCEC	ICGC	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.0556
p.G1153V	TCGA-AA-A010	COAD	TCGA	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation altering degron motif	0.6421
p.P1159S	TCGA-AA-A01P	COAD	TCGA	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation rewiring degron network	0.2222
p.P1159S	DO8642	COAD	ICGC	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation rewiring degron network	0.2222
p.L151I	TCGA-AP-A056	UCEC	TCGA	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1944
p.L151I	DO43971	UCEC	ICGC	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1944
p.R156C	TCGA-B5-A1MR	UCEC	TCGA	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.0556
p.R156C	DO41758	UCEC	ICGC	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.0556
p.A1162S	TCGA-B5-A1MU	UCEC	TCGA	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation rewiring degron network	0.1389
p.A1162S	DO41512	UCEC	ICGC	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation rewiring degron network	0.1389
p.I148L	TCGA-BG-A222	UCEC	TCGA	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.2778
p.I148L	DO42977	UCEC	ICGC	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.2778
p.G1140S	TCGA-DA-A95W	SKCM	TCGA	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation rewiring degron network	0.0556
p.G1140S	DO219479	SKCM	ICGC	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation rewiring degron network	0.0556
p.P1147S	TCGA-EB-A44O	SKCM	TCGA	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation rewiring degron network	0.25
p.P1147S	TCGA-FW-A3R5	SKCM	TCGA	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation rewiring degron network	0.25
p.P1147S	DO47272	SKCM	ICGC	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation rewiring degron network	0.25
p.P1147S	DO37406	SKCM	ICGC	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation rewiring degron network	0.25
p.L1154F	TCGA-EE-A29X	SKCM	TCGA	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation altering degron motif	0.587
p.L1154F	DO37595	SKCM	ICGC	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation altering degron motif	0.587
p.G1153E	TCGA-ER-A3PL	SKCM	TCGA	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation altering degron motif	0.6087
p.G1153E	DO8264	COAD	ICGC	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation altering degron motif	0.6087
p.G1153E	DO37495	SKCM	ICGC	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation altering degron motif	0.6087
p.R156H	TCGA-F4-6570	COAD	TCGA	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.0556
p.R156H	TCGA-IB-A6UG	PAAD	TCGA	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.0556
p.R156H	DO10443	COAD	ICGC	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.0556
p.R156H	DO49414	PAAD	ICGC	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.0556
p.S1141F	TCGA-GN-A4U4	SKCM	TCGA	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation blocking phosphorylation signal	0.5278
p.S1141F	DO51256	SKCM	ICGC	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation blocking phosphorylation signal	0.5278
p.I143T	DO50834	LIRI	ICGC	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.7078
p.F1156S	SIDM00157	Neuroblastoma	GDSC	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation rewiring degron network	0.3056
p.F1156S	ACH-002261	Neuroblastoma	CCLE	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation rewiring degron network	0.3056
p.F1156S	KP-N-YS	autonomic ganglia	COSMIC	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation rewiring degron network	0.3056
p.N145K	SIDM00587	Biliary Tract Carcinoma	GDSC	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.5806
p.N145K	ACH-000976	Bile Duct Cancer	CCLE	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.5806
p.N145K	HuCCT1	biliary tract	COSMIC	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.5806
p.E133K	SIDM00251	Gastric Carcinoma	GDSC	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1111
p.E133K	ACH-000949	Gastric Cancer	CCLE	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1111
p.E133K	TGBC11TKB	stomach	COSMIC	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1111
p.E147D	SIDM00534	Colorectal Carcinoma	GDSC	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.3056
p.E147D	ACH-000986	Colon/Colorectal Cancer	CCLE	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.3056
p.E147D	HT-115	large intestine	COSMIC	LEIYNE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.3056
p.P1152Q	SIDM01739	Small Cell Lung Carcinoma	GDSC	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation altering degron motif	0.7035
p.P1152Q	ACH-000297	Lung Cancer	CCLE	VTPGLS	DEG_SCF_FBW7_1	1150:1155	Mutation altering degron motif	0.7035

Kaplan plot for KIF4B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF4B

UniProt ID: Q2VIQ3

Entrez ID: 285643

Protein name: Chromosome-associated kinesin KIF4B (Chromokinesin-B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF4B in