DegronMD

Uniprot ID: Q2VIQ3

Source protein: Chromosome-associated kinesin KIF4B

Source gene: KIF4B

Class: LIG_APCC_ABBA_1

Location: 141:146

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6253

ASA_SCORE: 47.35

COIL: 0.3513

CONS_SCORE: 0.6535

DSS_SCORE: 0.018

HELIX: 0.2208

FCONS_SCORE: 1.2455

RIG_SCORE: 0.9276

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R156L	TCGA-60-2698	LUSC	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.0556
p.R156L	DO26469	LUSC	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.0556
p.D131G	TCGA-A5-A0GP	UCEC	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.0556
p.D131G	DO41109	UCEC	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.0556
p.L151I	TCGA-AP-A056	UCEC	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.1944
p.L151I	DO43971	UCEC	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.1944
p.R156C	TCGA-B5-A1MR	UCEC	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.0556
p.R156C	DO41758	UCEC	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.0556
p.I148L	TCGA-BG-A222	UCEC	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.2778
p.I148L	DO42977	UCEC	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.2778
p.R156H	TCGA-F4-6570	COAD	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.0556
p.R156H	TCGA-IB-A6UG	PAAD	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.0556
p.R156H	DO10443	COAD	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.0556
p.R156H	DO49414	PAAD	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.0556
p.I143T	DO50834	LIRI	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.7078
p.N145K	SIDM00587	Biliary Tract Carcinoma	GDSC	LEIYNE	LIG_APCC_ABBA_1	0.5806
p.N145K	ACH-000976	Bile Duct Cancer	CCLE	LEIYNE	LIG_APCC_ABBA_1	0.5806
p.N145K	HuCCT1	biliary_tract	COSMIC	LEIYNE	LIG_APCC_ABBA_1	0.5806
p.E133K	SIDM00251	Gastric Carcinoma	GDSC	LEIYNE	LIG_APCC_ABBA_1	0.1111
p.E133K	ACH-000949	Gastric Cancer	CCLE	LEIYNE	LIG_APCC_ABBA_1	0.1111
p.E133K	TGBC11TKB	stomach	COSMIC	LEIYNE	LIG_APCC_ABBA_1	0.1111
p.E147D	SIDM00534	Colorectal Carcinoma	GDSC	LEIYNE	LIG_APCC_ABBA_1	0.3056
p.E147D	ACH-000986	Colon/Colorectal Cancer	CCLE	LEIYNE	LIG_APCC_ABBA_1	0.3056
p.E147D	HT-115	large_intestine	COSMIC	LEIYNE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2VIQ3	Chromosome-associated kinesin KIF4B	LIG_APCC_ABBA_1	141:146	LEIYNE	APC,CDC20,FZR1	0.6253	More...
Q96L93	Kinesin-like protein KIF16B	LIG_APCC_ABBA_1	151:156	LEIYNE	APC,CDC20,FZR1	0.7637	More...
Q96FN5	Kinesin-like protein KIF12	LIG_APCC_ABBA_1	159:164	LEIYNE	APC,CDC20,FZR1	0.5147	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons