DegronMD - Q96FN5(KIF12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D169Y	TCGA-55-A490	LUAD	TCGA	LEIYNE	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.1944
p.D169Y	DO24596	LUAD	ICGC	LEIYNE	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.1944
p.E149Q	TCGA-85-A4QQ	LUSC	TCGA	LEIYNE	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.0556
p.E149Q	DO45427	LUSC	ICGC	LEIYNE	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.0556
p.S152N	TCGA-AA-A01P	COAD	TCGA	LEIYNE	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.1389
p.S152N	DO8642	COAD	ICGC	LEIYNE	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.1389
p.I153M	TCGA-CR-7370	HNSC	TCGA	LEIYNE	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.1667
p.I153M	DO14426	HNSC	ICGC	LEIYNE	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.1667
p.D169N	TCGA-EE-A2GR	SKCM	TCGA	LEIYNE	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.1944
p.D169N	DO37996	SKCM	ICGC	LEIYNE	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.1944
p.R155Q	TCGA-FI-A2D0	UCEC	TCGA	LEIYNE	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.2222
p.R155Q	DO43891	UCEC	ICGC	LEIYNE	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.2222
p.R155Q	SIDM00150	Colorectal Carcinoma	GDSC	LEIYNE	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.2222
p.R155Q	ACH-000969	Colon/Colorectal Cancer	CCLE	LEIYNE	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.2222
p.R172W	SIDM01113	Other Sarcomas	GDSC	LEIYNE	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.1111
p.R172W	ACH-000939	Sarcoma	CCLE	LEIYNE	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.1111
p.R172W	SK-UT-1	soft tissue	COSMIC	LEIYNE	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.1111
p.R172Q	SIDM00819	Kidney Carcinoma	GDSC	LEIYNE	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.1111
p.R172Q	RCC-FG2	kidney	COSMIC	LEIYNE	LIG_APCC_ABBA_1	159:164	Mutation rewiring degron network	0.1111
p.S589F	SW756	cervix	COSMIC	TEEEVVPSA	DEG_COP1_1	577:585	Mutation rewiring degron network	0.2222
p.S584F	SW756	cervix	COSMIC	TEEEVVPSA	DEG_COP1_1	577:585	Mutation altering degron motif	0.7982
p.M575I	TASK1	bone	COSMIC	TEEEVVPSA	DEG_COP1_1	577:585	Mutation rewiring degron network	0.2778
p.M575I	CCK-81	large intestine	COSMIC	TEEEVVPSA	DEG_COP1_1	577:585	Mutation rewiring degron network	0.2778
p.M580I	CCK-81	large intestine	COSMIC	TEEEVVPSA	DEG_COP1_1	577:585	Mutation altering degron motif	0.7618
p.M580I	TASK1	bone	COSMIC	TEEEVVPSA	DEG_COP1_1	577:585	Mutation altering degron motif	0.7618
p.P586A	CAL-54	kidney	COSMIC	TEEEVVPSA	DEG_COP1_1	577:585	Mutation rewiring degron network	0.3056
p.P591A	CAL-54	kidney	COSMIC	TEEEVVPSA	DEG_COP1_1	577:585	Mutation rewiring degron network	0.1667

Kaplan plot for KIF12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF12

UniProt ID: Q96FN5

Entrez ID: 113220

Protein name: Kinesin-like protein KIF12

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF12 in