DegronMD

Uniprot ID: Q96FN5

Source protein: Kinesin-like protein KIF12

Source gene: KIF12

Class: DEG_COP1_1

Location: 577:585

E3 ligase: COP1

DEGRON score: 0.9327

ASA_SCORE: 94.0667

COIL: 0.8257

CONS_SCORE: 0.6087

DSS_SCORE: 0.5762

HELIX: 0.1378

FCONS_SCORE: 1.1139

RIG_SCORE: 0.7288

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S589F	SW756	cervix	COSMIC	TEEEVVPSA	DEG_COP1_1	0.2222
p.S584F	SW756	cervix	COSMIC	TEEEVVPSA	DEG_COP1_1	0.7982
p.M575I	TASK1	bone	COSMIC	TEEEVVPSA	DEG_COP1_1	0.2778
p.M575I	CCK-81	large_intestine	COSMIC	TEEEVVPSA	DEG_COP1_1	0.2778
p.M580I	CCK-81	large_intestine	COSMIC	TEEEVVPSA	DEG_COP1_1	0.7618
p.M580I	TASK1	bone	COSMIC	TEEEVVPSA	DEG_COP1_1	0.7618
p.P586A	CAL-54	kidney	COSMIC	TEEEVVPSA	DEG_COP1_1	0.3056
p.P591A	CAL-54	kidney	COSMIC	TEEEVVPSA	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96FN5	Kinesin-like protein KIF12	DEG_COP1_1	577:585	TEEEVVPSA	COP1	0.9327	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons