DegronMD

Uniprot ID: Q96FN5

Source protein: Kinesin-like protein KIF12

Source gene: KIF12

Class: LIG_APCC_ABBA_1

Location: 159:164

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5147

ASA_SCORE: 31.1667

COIL: 0.386

CONS_SCORE: 0.9844

DSS_SCORE: 0.0532

HELIX: 0.161

FCONS_SCORE: 1.3867

RIG_SCORE: 0.8856

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D169Y	TCGA-55-A490	LUAD	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.1944
p.D169Y	DO24596	LUAD	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.1944
p.E149Q	TCGA-85-A4QQ	LUSC	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.0556
p.E149Q	DO45427	LUSC	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.0556
p.S152N	TCGA-AA-A01P	COAD	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.1389
p.S152N	DO8642	COAD	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.1389
p.I153M	TCGA-CR-7370	HNSC	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.I153M	DO14426	HNSC	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.D169N	TCGA-EE-A2GR	SKCM	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.1944
p.D169N	DO37996	SKCM	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.1944
p.R155Q	TCGA-FI-A2D0	UCEC	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.2222
p.R155Q	DO43891	UCEC	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.2222
p.R155Q	SIDM00150	Colorectal Carcinoma	GDSC	LEIYNE	LIG_APCC_ABBA_1	0.2222
p.R155Q	ACH-000969	Colon/Colorectal Cancer	CCLE	LEIYNE	LIG_APCC_ABBA_1	0.2222
p.R172W	SIDM01113	Other Sarcomas	GDSC	LEIYNE	LIG_APCC_ABBA_1	0.1111
p.R172W	ACH-000939	Sarcoma	CCLE	LEIYNE	LIG_APCC_ABBA_1	0.1111
p.R172W	SK-UT-1	soft_tissue	COSMIC	LEIYNE	LIG_APCC_ABBA_1	0.1111
p.R172Q	SIDM00819	Kidney Carcinoma	GDSC	LEIYNE	LIG_APCC_ABBA_1	0.1111
p.R172Q	RCC-FG2	kidney	COSMIC	LEIYNE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2VIQ3	Chromosome-associated kinesin KIF4B	LIG_APCC_ABBA_1	141:146	LEIYNE	APC,CDC20,FZR1	0.6253	More...
Q96L93	Kinesin-like protein KIF16B	LIG_APCC_ABBA_1	151:156	LEIYNE	APC,CDC20,FZR1	0.7637	More...
Q96FN5	Kinesin-like protein KIF12	LIG_APCC_ABBA_1	159:164	LEIYNE	APC,CDC20,FZR1	0.5147	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons