DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LEIYNE
Uniprot ID:
Q96L93
Source protein:
Kinesin-like protein KIF16B
Source gene:
KIF16B
Class:
LIG_APCC_ABBA_1
Location:
151:156
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7637
ASA_SCORE:
55.7
COIL:
0.3452
CONS_SCORE:
0.8297
DSS_SCORE:
0.1125
HELIX:
0.094
FCONS_SCORE:
1.5478
RIG_SCORE:
0.8908
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E156K
TCGA-3P-A9WA
OV
TCGA
LEIYNE
LIG_APCC_ABBA_1
0.7022
p.E156K
TCGA-AZ-4315
COAD
TCGA
LEIYNE
LIG_APCC_ABBA_1
0.7022
p.E156K
TCGA-B5-A11E
UCEC
TCGA
LEIYNE
LIG_APCC_ABBA_1
0.7022
p.E156K
DO8842
COAD
ICGC
LEIYNE
LIG_APCC_ABBA_1
0.7022
p.E156K
DO50655
OV
ICGC
LEIYNE
LIG_APCC_ABBA_1
0.7022
p.E156K
DO41644
UCEC
ICGC
LEIYNE
LIG_APCC_ABBA_1
0.7022
p.L151V
DO225132
BRCA
ICGC
LEIYNE
LIG_APCC_ABBA_1
0.5654
p.R157C
DO49422
PACA
ICGC
LEIYNE
LIG_APCC_ABBA_1
0.3056
p.V158M
TCGA-85-8071
LUSC
TCGA
LEIYNE
LIG_APCC_ABBA_1
0.2778
p.V158M
DO26755
LUSC
ICGC
LEIYNE
LIG_APCC_ABBA_1
0.2778
p.R145Q
TCGA-AA-A00N
COAD
TCGA
LEIYNE
LIG_APCC_ABBA_1
0.1667
p.R145Q
TCGA-AG-A002
READ
TCGA
LEIYNE
LIG_APCC_ABBA_1
0.1667
p.R145Q
TCGA-AJ-A3EL
UCEC
TCGA
LEIYNE
LIG_APCC_ABBA_1
0.1667
p.R145Q
TCGA-AJ-A5DW
UCEC
TCGA
LEIYNE
LIG_APCC_ABBA_1
0.1667
p.R145Q
TCGA-AN-A046
BRCA
TCGA
LEIYNE
LIG_APCC_ABBA_1
0.1667
p.R145Q
TCGA-AX-A05Z
UCEC
TCGA
LEIYNE
LIG_APCC_ABBA_1
0.1667
p.R145Q
TCGA-CA-6717
COAD
TCGA
LEIYNE
LIG_APCC_ABBA_1
0.1667
p.R145Q
TCGA-D1-A17Q
UCEC
TCGA
LEIYNE
LIG_APCC_ABBA_1
0.1667
p.R145Q
DO1285
BRCA
ICGC
LEIYNE
LIG_APCC_ABBA_1
0.1667
p.R145Q
DO9876
COAD
ICGC
LEIYNE
LIG_APCC_ABBA_1
0.1667
p.R145Q
DO8264
COAD
ICGC
LEIYNE
LIG_APCC_ABBA_1
0.1667
p.R145Q
DO222762
COCA
ICGC
LEIYNE
LIG_APCC_ABBA_1
0.1667
p.R145Q
DO36556
READ
ICGC
LEIYNE
LIG_APCC_ABBA_1
0.1667
p.R145Q
DO40884
UCEC
ICGC
LEIYNE
LIG_APCC_ABBA_1
0.1667
p.R145Q
DO50075
UCEC
ICGC
LEIYNE
LIG_APCC_ABBA_1
0.1667
Showing 1 to 25 of 34 entries
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Drug responses associated with KIF16B mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of LEIYNE
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q2VIQ3
Chromosome-associated kinesin KIF4B
LIG_APCC_ABBA_1
141:146
LEIYNE
APC,CDC20,FZR1
0.6253
More...
Q96FN5
Kinesin-like protein KIF12
LIG_APCC_ABBA_1
159:164
LEIYNE
APC,CDC20,FZR1
0.5147
More...
Q96L93
Kinesin-like protein KIF16B
LIG_APCC_ABBA_1
151:156
LEIYNE
APC,CDC20,FZR1
0.7637
More...
Showing 1 to 3 of 3 entries
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