DegronMD

Uniprot ID: Q96L93

Source protein: Kinesin-like protein KIF16B

Source gene: KIF16B

Class: LIG_APCC_ABBA_1

Location: 151:156

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7637

ASA_SCORE: 55.7

COIL: 0.3452

CONS_SCORE: 0.8297

DSS_SCORE: 0.1125

HELIX: 0.094

FCONS_SCORE: 1.5478

RIG_SCORE: 0.8908

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R163L	TCGA-34-2596	LUSC	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.1389
p.R163L	DO26508	LUSC	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.1389
p.E156K	TCGA-3P-A9WA	OV	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.7022
p.E156K	TCGA-AZ-4315	COAD	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.7022
p.E156K	TCGA-B5-A11E	UCEC	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.7022
p.E156K	DO8842	COAD	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.7022
p.E156K	DO50655	OV	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.7022
p.E156K	DO41644	UCEC	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.7022
p.V158M	TCGA-85-8071	LUSC	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.2778
p.V158M	DO26755	LUSC	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.2778
p.R145Q	TCGA-AA-A00N	COAD	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.R145Q	TCGA-AG-A002	READ	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.R145Q	TCGA-AJ-A3EL	UCEC	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.R145Q	TCGA-AJ-A5DW	UCEC	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.R145Q	TCGA-AN-A046	BRCA	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.R145Q	TCGA-AX-A05Z	UCEC	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.R145Q	TCGA-CA-6717	COAD	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.R145Q	TCGA-D1-A17Q	UCEC	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.R145Q	DO1285	BRCA	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.R145Q	DO9876	COAD	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.R145Q	DO8264	COAD	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.R145Q	DO222762	COCA	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.R145Q	DO36556	READ	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.R145Q	DO40884	UCEC	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.R145Q	DO50075	UCEC	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.R145Q	DO41542	UCEC	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.R145Q	DO41903	UCEC	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.R145Q	MCC13	skin	COSMIC	LEIYNE	LIG_APCC_ABBA_1	0.1667
p.S166L	TCGA-VQ-A91N	STAD	TCGA	LEIYNE	LIG_APCC_ABBA_1	0.0556
p.S166L	DO222351	STAD	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.0556
p.R164W	DO225109	BRCA	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.1111
p.L151V	DO225132	BRCA	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.5654
p.R163W	DO222880	MELA	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.1389
p.R157C	DO49422	PACA	ICGC	LEIYNE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2VIQ3	Chromosome-associated kinesin KIF4B	LIG_APCC_ABBA_1	141:146	LEIYNE	APC,CDC20,FZR1	0.6253	More...
Q96L93	Kinesin-like protein KIF16B	LIG_APCC_ABBA_1	151:156	LEIYNE	APC,CDC20,FZR1	0.7637	More...
Q96FN5	Kinesin-like protein KIF12	LIG_APCC_ABBA_1	159:164	LEIYNE	APC,CDC20,FZR1	0.5147	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LEIYNE

Degron related mutations and impact score

Drug responses associated with KIF16B mutations

All proteins holding degron of LEIYNE