DegronMD

Uniprot ID: Q14CN2

Source protein: Calcium-activated chloride channel regulator 4

Source gene: CLCA4

Class: DEG_MDM2_SWIB_1

Location: 269:276

E3 ligase: MDM2

DEGRON score: 0.5624

ASA_SCORE: 58.45

COIL: 0.4601

CONS_SCORE: 0.5955

DSS_SCORE: 0.2675

HELIX: 0.4271

FCONS_SCORE: 1.1949

RIG_SCORE: 0.8112

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L262I	TCGA-50-6594	LUAD	TCGA	FRSTWEVI	DEG_MDM2_SWIB_1	0.1389
p.L262I	DO24275	LUAD	ICGC	FRSTWEVI	DEG_MDM2_SWIB_1	0.1389
p.I286V	TCGA-AP-A059	UCEC	TCGA	FRSTWEVI	DEG_MDM2_SWIB_1	0.0556
p.I286V	DO41361	UCEC	ICGC	FRSTWEVI	DEG_MDM2_SWIB_1	0.0556
p.T272A	TCGA-FI-A2D5	UCEC	TCGA	FRSTWEVI	DEG_MDM2_SWIB_1	0.6028
p.T272A	DO41331	UCEC	ICGC	FRSTWEVI	DEG_MDM2_SWIB_1	0.6028
p.F269I	TCGA-ND-A4WC	UCS	TCGA	FRSTWEVI	DEG_MDM2_SWIB_1	0.7415
p.T272S	DO227929	PBCA	ICGC	FRSTWEVI	DEG_MDM2_SWIB_1	0.6005
p.S271G	SIDM00120	Prostate Carcinoma	GDSC	FRSTWEVI	DEG_MDM2_SWIB_1	0.5882
p.S271G	ACH-000979	Prostate Cancer	CCLE	FRSTWEVI	DEG_MDM2_SWIB_1	0.5882
p.S271G	DU-145	prostate	COSMIC	FRSTWEVI	DEG_MDM2_SWIB_1	0.5882

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14CN2	Calcium-activated chloride channel regulator 4	DEG_MDM2_SWIB_1	269:276	FRSTWEVI	MDM2	0.5624	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons