DegronMD - Q14CN2(CLCA4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L262I	TCGA-50-6594	LUAD	TCGA	FRSTWEVI	DEG_MDM2_SWIB_1	269:276	Mutation rewiring degron network	0.1389
p.L262I	DO24275	LUAD	ICGC	FRSTWEVI	DEG_MDM2_SWIB_1	269:276	Mutation rewiring degron network	0.1389
p.A870S	TCGA-50-6594	LUAD	TCGA	IDPTPTPT	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.1944
p.A870S	DO24275	LUAD	ICGC	IDPTPTPT	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.1944
p.I286V	TCGA-AP-A059	UCEC	TCGA	FRSTWEVI	DEG_MDM2_SWIB_1	269:276	Mutation rewiring degron network	0.0556
p.I286V	DO41361	UCEC	ICGC	FRSTWEVI	DEG_MDM2_SWIB_1	269:276	Mutation rewiring degron network	0.0556
p.P868S	TCGA-EE-A2A1	SKCM	TCGA	IDPTPTPT	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.1389
p.P868S	DO38045	SKCM	ICGC	IDPTPTPT	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.1389
p.N892T	TCGA-EO-A22U	UCEC	TCGA	IDPTPTPT	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.0556
p.N892T	DO43755	UCEC	ICGC	IDPTPTPT	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.0556
p.T272A	TCGA-FI-A2D5	UCEC	TCGA	FRSTWEVI	DEG_MDM2_SWIB_1	269:276	Mutation altering degron motif	0.6028
p.T272A	DO41331	UCEC	ICGC	FRSTWEVI	DEG_MDM2_SWIB_1	269:276	Mutation altering degron motif	0.6028
p.P881S	TCGA-FW-A3R5	SKCM	TCGA	IDPTPTPT	DEG_SCF_FBW7_1	875:882	Mutation altering degron motif	0.5641
p.P881S	DO37406	SKCM	ICGC	IDPTPTPT	DEG_SCF_FBW7_1	875:882	Mutation altering degron motif	0.5641
p.F269I	TCGA-ND-A4WC	UCS	TCGA	FRSTWEVI	DEG_MDM2_SWIB_1	269:276	Mutation altering degron motif	0.7415
p.P872S	TCGA-VS-A9V5	CESC	TCGA	IDPTPTPT	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.25
p.P872S	DO51650	CESC	ICGC	IDPTPTPT	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.25
p.P872S	DO222875	MELA	ICGC	IDPTPTPT	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.25
p.P872L	DO222743	MELA	ICGC	IDPTPTPT	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.25
p.T272S	DO227929	PBCA	ICGC	FRSTWEVI	DEG_MDM2_SWIB_1	269:276	Mutation altering degron motif	0.6005
p.S271G	SIDM00120	Prostate Carcinoma	GDSC	FRSTWEVI	DEG_MDM2_SWIB_1	269:276	Mutation altering degron motif	0.5882
p.S271G	ACH-000979	Prostate Cancer	CCLE	FRSTWEVI	DEG_MDM2_SWIB_1	269:276	Mutation altering degron motif	0.5882
p.S271G	DU-145	prostate	COSMIC	FRSTWEVI	DEG_MDM2_SWIB_1	269:276	Mutation altering degron motif	0.5882
p.D888N	GEO	large intestine	COSMIC	IDPTPTPT	DEG_SCF_FBW7_1	875:882	Mutation rewiring degron network	0.1667

Kaplan plot for CLCA4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLCA4

UniProt ID: Q14CN2

Entrez ID: 22802

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLCA4 in