DegronMD

Uniprot ID: Q14CN2

Source protein: Calcium-activated chloride channel regulator 4

Source gene: CLCA4

Class: DEG_SCF_FBW7_1

Location: 875:882

E3 ligase: FBXW7

DEGRON score: 0.7235

ASA_SCORE: 89.275

COIL: 0.9695

CONS_SCORE: 0.3378

DSS_SCORE: 0.7935

HELIX: 0.0084

FCONS_SCORE: 1.0001

RIG_SCORE: 0.6186

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A870S	TCGA-50-6594	LUAD	TCGA	IDPTPTPT	DEG_SCF_FBW7_1	0.1944
p.A870S	DO24275	LUAD	ICGC	IDPTPTPT	DEG_SCF_FBW7_1	0.1944
p.P868S	TCGA-EE-A2A1	SKCM	TCGA	IDPTPTPT	DEG_SCF_FBW7_1	0.1389
p.P868S	DO38045	SKCM	ICGC	IDPTPTPT	DEG_SCF_FBW7_1	0.1389
p.N892T	TCGA-EO-A22U	UCEC	TCGA	IDPTPTPT	DEG_SCF_FBW7_1	0.0556
p.N892T	DO43755	UCEC	ICGC	IDPTPTPT	DEG_SCF_FBW7_1	0.0556
p.P881S	TCGA-FW-A3R5	SKCM	TCGA	IDPTPTPT	DEG_SCF_FBW7_1	0.5641
p.P881S	DO37406	SKCM	ICGC	IDPTPTPT	DEG_SCF_FBW7_1	0.5641
p.P872S	TCGA-VS-A9V5	CESC	TCGA	IDPTPTPT	DEG_SCF_FBW7_1	0.25
p.P872S	DO51650	CESC	ICGC	IDPTPTPT	DEG_SCF_FBW7_1	0.25
p.P872S	DO222875	MELA	ICGC	IDPTPTPT	DEG_SCF_FBW7_1	0.25
p.P872L	DO222743	MELA	ICGC	IDPTPTPT	DEG_SCF_FBW7_1	0.25
p.D888N	GEO	large_intestine	COSMIC	IDPTPTPT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14CN2	Calcium-activated chloride channel regulator 4	DEG_SCF_FBW7_1	875:882	IDPTPTPT	FBXW7	0.7235	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons