DegronMD

Uniprot ID: Q96HU1

Source protein: Small G protein signaling modulator 3

Source gene: SGSM3

Class: LIG_APCC_ABBA_1

Location: 47:52

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6319

ASA_SCORE: 90.3

COIL: 0.6538

CONS_SCORE: 0.4009

DSS_SCORE: 0.4169

HELIX: 0.0192

FCONS_SCORE: 1.0834

RIG_SCORE: 0.7897

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E44K	TCGA-AD-A5EJ	COAD	TCGA	FRVYKE	LIG_APCC_ABBA_1	0.25
p.E44K	DO50090	COAD	ICGC	FRVYKE	LIG_APCC_ABBA_1	0.25
p.D43N	TCGA-EO-A22R	UCEC	TCGA	FRVYKE	LIG_APCC_ABBA_1	0.2222
p.D43N	DO42713	UCEC	ICGC	FRVYKE	LIG_APCC_ABBA_1	0.2222
p.R48H	TCGA-FI-A2F4	UCEC	TCGA	FRVYKE	LIG_APCC_ABBA_1	0.7133
p.R48H	DO43434	UCEC	ICGC	FRVYKE	LIG_APCC_ABBA_1	0.7133
p.E44Q	TCGA-NC-A5HO	LUSC	TCGA	FRVYKE	LIG_APCC_ABBA_1	0.25
p.E44Q	DO219197	LUSC	ICGC	FRVYKE	LIG_APCC_ABBA_1	0.25
p.G46S	DO234242	ESAD	ICGC	FRVYKE	LIG_APCC_ABBA_1	0.3056
p.R48C	DO230525	LUSC	ICGC	FRVYKE	LIG_APCC_ABBA_1	0.719
p.R48C	DO230550	LUSC	ICGC	FRVYKE	LIG_APCC_ABBA_1	0.719
p.R48C	DO231049	LUSC	ICGC	FRVYKE	LIG_APCC_ABBA_1	0.719
p.R48C	SIDM01045	Endometrial Carcinoma	GDSC	FRVYKE	LIG_APCC_ABBA_1	0.719
p.R48C	EN	endometrium	COSMIC	FRVYKE	LIG_APCC_ABBA_1	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96HU1	Small G protein signaling modulator 3	LIG_APCC_ABBA_1	47:52	FRVYKE	APC,CDC20,FZR1	0.6319	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons