DegronMD - Q96HU1(SGSM3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R469L	TCGA-3B-A9HZ	SARC	TCGA	VELTPDYS	DEG_SCF_FBW7_1	456:463	Mutation rewiring degron network	0.1667
p.R469L	DO229015	LICA	ICGC	VELTPDYS	DEG_SCF_FBW7_1	456:463	Mutation rewiring degron network	0.1667
p.R469L	DO219939	SARC	ICGC	VELTPDYS	DEG_SCF_FBW7_1	456:463	Mutation rewiring degron network	0.1667
p.E44K	TCGA-AD-A5EJ	COAD	TCGA	FRVYKE	LIG_APCC_ABBA_1	47:52	Mutation rewiring degron network	0.25
p.E44K	DO50090	COAD	ICGC	FRVYKE	LIG_APCC_ABBA_1	47:52	Mutation rewiring degron network	0.25
p.E472K	TCGA-DS-A0VL	CESC	TCGA	VELTPDYS	DEG_SCF_FBW7_1	456:463	Mutation rewiring degron network	0.0833
p.E472K	DO222817	BTCA	ICGC	VELTPDYS	DEG_SCF_FBW7_1	456:463	Mutation rewiring degron network	0.0833
p.E472K	DO6332	CESC	ICGC	VELTPDYS	DEG_SCF_FBW7_1	456:463	Mutation rewiring degron network	0.0833
p.D43N	TCGA-EO-A22R	UCEC	TCGA	FRVYKE	LIG_APCC_ABBA_1	47:52	Mutation rewiring degron network	0.2222
p.D43N	DO42713	UCEC	ICGC	FRVYKE	LIG_APCC_ABBA_1	47:52	Mutation rewiring degron network	0.2222
p.R48H	TCGA-FI-A2F4	UCEC	TCGA	FRVYKE	LIG_APCC_ABBA_1	47:52	Mutation altering degron motif	0.7133
p.R48H	DO43434	UCEC	ICGC	FRVYKE	LIG_APCC_ABBA_1	47:52	Mutation altering degron motif	0.7133
p.S463I	TCGA-IB-7651	PAAD	TCGA	VELTPDYS	DEG_SCF_FBW7_1	456:463	Mutation altering degron motif	0.8453
p.S463I	DO46657	PAAD	ICGC	VELTPDYS	DEG_SCF_FBW7_1	456:463	Mutation altering degron motif	0.8453
p.E44Q	TCGA-NC-A5HO	LUSC	TCGA	FRVYKE	LIG_APCC_ABBA_1	47:52	Mutation rewiring degron network	0.25
p.E44Q	DO219197	LUSC	ICGC	FRVYKE	LIG_APCC_ABBA_1	47:52	Mutation rewiring degron network	0.25
p.G46S	DO234242	ESAD	ICGC	FRVYKE	LIG_APCC_ABBA_1	47:52	Mutation rewiring degron network	0.3056
p.R48C	DO230525	LUSC	ICGC	FRVYKE	LIG_APCC_ABBA_1	47:52	Mutation altering degron motif	0.719
p.R48C	DO230550	LUSC	ICGC	FRVYKE	LIG_APCC_ABBA_1	47:52	Mutation altering degron motif	0.719
p.R48C	DO231049	LUSC	ICGC	FRVYKE	LIG_APCC_ABBA_1	47:52	Mutation altering degron motif	0.719
p.R48C	SIDM01045	Endometrial Carcinoma	GDSC	FRVYKE	LIG_APCC_ABBA_1	47:52	Mutation altering degron motif	0.719
p.R48C	EN	endometrium	COSMIC	FRVYKE	LIG_APCC_ABBA_1	47:52	Mutation altering degron motif	0.719
p.P451R	DO46611	OV	ICGC	VELTPDYS	DEG_SCF_FBW7_1	456:463	Mutation rewiring degron network	0.1944
p.D461H	DO228152	PBCA	ICGC	VELTPDYS	DEG_SCF_FBW7_1	456:463	Mutation altering degron motif	0.6577
p.R469Q	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VELTPDYS	DEG_SCF_FBW7_1	456:463	Mutation rewiring degron network	0.1667
p.R469Q	CML-T1	haematopoietic and lymphoid tissue	COSMIC	VELTPDYS	DEG_SCF_FBW7_1	456:463	Mutation rewiring degron network	0.1667
p.R469W	SIDM00660	Colorectal Carcinoma	GDSC	VELTPDYS	DEG_SCF_FBW7_1	456:463	Mutation rewiring degron network	0.1667
p.R469W	LS-411N	large intestine	COSMIC	VELTPDYS	DEG_SCF_FBW7_1	456:463	Mutation rewiring degron network	0.1667

Kaplan plot for SGSM3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SGSM3

UniProt ID: Q96HU1

Entrez ID: 27352

Protein name: Small G protein signaling modulator 3 (Merlin-associated protein) (RUN and TBC1 domain-containing protein 3) (Rab-GTPase-activating protein-like protein) (RabGAPLP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SGSM3 in