DegronMD

Uniprot ID: Q96HU1

Source protein: Small G protein signaling modulator 3

Source gene: SGSM3

Class: DEG_SCF_FBW7_1

Location: 456:463

E3 ligase: FBXW7

DEGRON score: 0.9992

ASA_SCORE: 62.9

COIL: 0.7653

CONS_SCORE: 0.4183

DSS_SCORE: 0.3962

HELIX: 0.0994

FCONS_SCORE: 1.0609

RIG_SCORE: 0.7357

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R469L	TCGA-3B-A9HZ	SARC	TCGA	VELTPDYS	DEG_SCF_FBW7_1	0.1667
p.R469L	DO229015	LICA	ICGC	VELTPDYS	DEG_SCF_FBW7_1	0.1667
p.R469L	DO219939	SARC	ICGC	VELTPDYS	DEG_SCF_FBW7_1	0.1667
p.E472K	TCGA-DS-A0VL	CESC	TCGA	VELTPDYS	DEG_SCF_FBW7_1	0.0833
p.E472K	DO222817	BTCA	ICGC	VELTPDYS	DEG_SCF_FBW7_1	0.0833
p.E472K	DO6332	CESC	ICGC	VELTPDYS	DEG_SCF_FBW7_1	0.0833
p.S463I	TCGA-IB-7651	PAAD	TCGA	VELTPDYS	DEG_SCF_FBW7_1	0.8453
p.S463I	DO46657	PAAD	ICGC	VELTPDYS	DEG_SCF_FBW7_1	0.8453
p.P451R	DO46611	OV	ICGC	VELTPDYS	DEG_SCF_FBW7_1	0.1944
p.D461H	DO228152	PBCA	ICGC	VELTPDYS	DEG_SCF_FBW7_1	0.6577
p.R469Q	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VELTPDYS	DEG_SCF_FBW7_1	0.1667
p.R469Q	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VELTPDYS	DEG_SCF_FBW7_1	0.1667
p.R469W	SIDM00660	Colorectal Carcinoma	GDSC	VELTPDYS	DEG_SCF_FBW7_1	0.1667
p.R469W	LS-411N	large_intestine	COSMIC	VELTPDYS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96HU1	Small G protein signaling modulator 3	DEG_SCF_FBW7_1	456:463	VELTPDYS	FBXW7	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons