DegronMD

Uniprot ID: P06731

Source protein: Carcinoembryonic antigen-related cell adhesion molecule 5

Source gene: CEACAM5

Class: LIG_APCC_ABBA_1

Location: 138:143

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7858

ASA_SCORE: 61.2833

COIL: 0.3418

CONS_SCORE: 0.5612

DSS_SCORE: 0.4284

HELIX: 0.002

FCONS_SCORE: 1.1332

RIG_SCORE: 0.8191

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T135A	DO52582	BOCA	ICGC	FRVYPE	LIG_APCC_ABBA_1	0.25
p.P142L	DO222492	COCA	ICGC	FRVYPE	LIG_APCC_ABBA_1	0.6471
p.P142L	DO228581	GACA	ICGC	FRVYPE	LIG_APCC_ABBA_1	0.6471
p.P142L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	FRVYPE	LIG_APCC_ABBA_1	0.6471
p.P142L	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	FRVYPE	LIG_APCC_ABBA_1	0.6471
p.Q137P	DO229005	COCA	ICGC	FRVYPE	LIG_APCC_ABBA_1	0.3056
p.Q137P	SIDM00157	Neuroblastoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	0.3056
p.Q137P	SIDM00590	Oral Cavity Carcinoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	0.3056
p.Q137P	SIDM00293	Small Cell Lung Carcinoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	0.3056
p.Q137P	SIDM00571	Pancreatic Carcinoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	0.3056
p.Q137P	SIDM00574	Glioblastoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	0.3056
p.Q137P	SIDM00580	Acute Myeloid Leukemia	GDSC	FRVYPE	LIG_APCC_ABBA_1	0.3056
p.Q137P	SIDM00531	Pancreatic Carcinoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	0.3056
p.Q137P	SIDM01412	Oral Cavity Carcinoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	0.3056
p.Q137P	SIDM01559	Melanoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	0.3056
p.Q137P	SIDM01451	Pancreatic Carcinoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	0.3056
p.Q137P	SIDM01756	Chronic Myelogenous Leukemia	GDSC	FRVYPE	LIG_APCC_ABBA_1	0.3056
p.A134S	DO229037	LICA	ICGC	FRVYPE	LIG_APCC_ABBA_1	0.2222
p.G136S	DO26749	LUSC	ICGC	FRVYPE	LIG_APCC_ABBA_1	0.2778
p.R139Q	DO42633	UCEC	ICGC	FRVYPE	LIG_APCC_ABBA_1	0.6218
p.P142S	SIDM00353	Other Sarcomas	GDSC	FRVYPE	LIG_APCC_ABBA_1	0.5641
p.P142S	RKN	ovary	COSMIC	FRVYPE	LIG_APCC_ABBA_1	0.5641
p.D128Y	SIDM00413	B-Cell Non-Hodgkin's Lymphoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	0.0556
p.D128Y	ACH-000534	Lymphoma	CCLE	FRVYPE	LIG_APCC_ABBA_1	0.0556
p.D128Y	WSU-DLCL2	haematopoietic_and_lymphoid_tissue	COSMIC	FRVYPE	LIG_APCC_ABBA_1	0.0556
p.T135I	SIDM00223	Small Cell Lung Carcinoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	0.25
p.T135I	ACH-002144	Lung Cancer	CCLE	FRVYPE	LIG_APCC_ABBA_1	0.25
p.T135I	IST-SL1	lung	COSMIC	FRVYPE	LIG_APCC_ABBA_1	0.25
p.D128V	SIDM00205	Ewing's Sarcoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	0.0556
p.D128V	ACH-002110	Bone Cancer	CCLE	FRVYPE	LIG_APCC_ABBA_1	0.0556
p.D128V	EW-1	bone	COSMIC	FRVYPE	LIG_APCC_ABBA_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FRVYPE

Degron related mutations and impact score

Drug responses associated with CEACAM5 mutations

All proteins holding degron of FRVYPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P06731	Carcinoembryonic antigen-related cell adhesion molecule 5	LIG_APCC_ABBA_1	138:143	FRVYPE	APC,CDC20,FZR1	0.7858	More...