DegronMD - P06731(CEACAM5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P323L	TCGA-A5-A0G1	UCEC	TCGA	ITVYAE	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.2778
p.P323L	DO42472	UCEC	ICGC	ITVYAE	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.2778
p.T135A	DO52582	BOCA	ICGC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.25
p.P142L	DO222492	COCA	ICGC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.6471
p.P142L	DO228581	GACA	ICGC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.6471
p.P142L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.6471
p.P142L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.6471
p.Q137P	DO229005	COCA	ICGC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.3056
p.Q137P	SIDM00157	Neuroblastoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.3056
p.Q137P	SIDM00590	Oral Cavity Carcinoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.3056
p.Q137P	SIDM00293	Small Cell Lung Carcinoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.3056
p.Q137P	SIDM00571	Pancreatic Carcinoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.3056
p.Q137P	SIDM00574	Glioblastoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.3056
p.Q137P	SIDM00580	Acute Myeloid Leukemia	GDSC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.3056
p.Q137P	SIDM00531	Pancreatic Carcinoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.3056
p.Q137P	SIDM01412	Oral Cavity Carcinoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.3056
p.Q137P	SIDM01559	Melanoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.3056
p.Q137P	SIDM01451	Pancreatic Carcinoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.3056
p.Q137P	SIDM01756	Chronic Myelogenous Leukemia	GDSC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.3056
p.A134S	DO229037	LICA	ICGC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.2222
p.G136S	DO26749	LUSC	ICGC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.2778
p.R139Q	DO42633	UCEC	ICGC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.6218
p.T306I	SIDM01280	Esophageal Carcinoma	GDSC	ITVYAE	LIG_APCC_ABBA_1	316:321	Mutation rewiring degron network	0.0556
p.P142S	SIDM00353	Other Sarcomas	GDSC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5641
p.P142S	RKN	ovary	COSMIC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation altering degron motif	0.5641
p.D128Y	SIDM00413	B-Cell Non-Hodgkin's Lymphoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0556
p.D128Y	ACH-000534	Lymphoma	CCLE	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0556
p.D128Y	WSU-DLCL2	haematopoietic and lymphoid tissue	COSMIC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0556
p.T135I	SIDM00223	Small Cell Lung Carcinoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.25
p.T135I	ACH-002144	Lung Cancer	CCLE	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.25
p.T135I	IST-SL1	lung	COSMIC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.25
p.D128V	SIDM00205	Ewing's Sarcoma	GDSC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0556
p.D128V	ACH-002110	Bone Cancer	CCLE	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0556
p.D128V	EW-1	bone	COSMIC	FRVYPE	LIG_APCC_ABBA_1	138:143	Mutation rewiring degron network	0.0556
p.A320V	NOS-1	bone	COSMIC	ITVYAE	LIG_APCC_ABBA_1	316:321	Mutation altering degron motif	0.5825

Kaplan plot for CEACAM5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEACAM5

UniProt ID: P06731

Entrez ID: 1048

Protein name: Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEACAM5 in