DegronMD

Uniprot ID: P06731

Source protein: Carcinoembryonic antigen-related cell adhesion molecule 5

Source gene: CEACAM5

Class: LIG_APCC_ABBA_1

Location: 316:321

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8389

ASA_SCORE: 53.8167

COIL: 0.288

CONS_SCORE: 0.4903

DSS_SCORE: 0.4183

HELIX: 0.0018

FCONS_SCORE: 1.1275

RIG_SCORE: 0.847

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P323L	TCGA-A5-A0G1	UCEC	TCGA	ITVYAE	LIG_APCC_ABBA_1	0.2778
p.P323L	DO42472	UCEC	ICGC	ITVYAE	LIG_APCC_ABBA_1	0.2778
p.T306I	SIDM01280	Esophageal Carcinoma	GDSC	ITVYAE	LIG_APCC_ABBA_1	0.0556
p.A320V	NOS-1	bone	COSMIC	ITVYAE	LIG_APCC_ABBA_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P06731	Carcinoembryonic antigen-related cell adhesion molecule 5	LIG_APCC_ABBA_1	316:321	ITVYAE	APC,CDC20,FZR1	0.8389	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons